AlzGene - Polymorphism Details
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 Study: Prince, 2003
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 13

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1999764 (IDE_18) Scotland AD
CTR
0.10
0.09
0.90
0.91
0 (0.000)
2 (0.013)
24 (0.203)
22 (0.145)
94 (0.797)
128 (0.842)
rs1999764 (IDE_18) Sweden AD
CTR
0.09
0.08
0.91
0.92
3 (0.008)
1 (0.006)
64 (0.168)
27 (0.157)
315 (0.825)
144 (0.837)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs1832196 (IDE_14) Scotland AD
CTR
0.15
0.12
0.85
0.88
2 (0.017)
4 (0.027)
32 (0.264)
29 (0.195)
87 (0.719)
116 (0.779)
rs1832196 (IDE_14) Sweden AD
CTR
0.18
0.18
0.82
0.82
8 (0.021)
9 (0.051)
120 (0.311)
46 (0.263)
258 (0.668)
120 (0.686)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs1832197 (IDE_16) Scotland AD
CTR
0.36
0.38
0.64
0.62
18 (0.151)
17 (0.113)
50 (0.420)
81 (0.536)
51 (0.429)
53 (0.351)
rs1832197 (IDE_16) Sweden AD
CTR
0.46
0.44
0.54
0.56
79 (0.206)
29 (0.167)
192 (0.501)
96 (0.552)
112 (0.292)
49 (0.282)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1887922 Scotland AD
CTR
0.19
0.23
0.81
0.77
3 (0.025)
7 (0.047)
39 (0.322)
56 (0.373)
79 (0.653)
87 (0.580)
rs1887922 Sweden AD
CTR
0.17
0.17
0.83
0.83
9 (0.023)
3 (0.017)
117 (0.303)
52 (0.297)
260 (0.674)
120 (0.686)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2149632 (IDE_12) Scotland AD
CTR
0.38
0.35
0.62
0.65
23 (0.192)
19 (0.126)
46 (0.383)
67 (0.444)
51 (0.425)
65 (0.430)
rs2149632 (IDE_12) Sweden AD
CTR
0.35
0.35
0.65
0.65
47 (0.123)
22 (0.126)
176 (0.462)
79 (0.451)
158 (0.415)
74 (0.423)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs2249960 Scotland AD
CTR
0.11
0.16
0.89
0.84
1 (0.008)
4 (0.028)
25 (0.210)
39 (0.273)
93 (0.782)
100 (0.699)
rs2249960 Sweden AD
CTR
0.13
0.11
0.87
0.89
3 (0.008)
2 (0.012)
92 (0.242)
35 (0.203)
285 (0.750)
135 (0.785)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2250090 (IDE_11) Scotland AD
CTR
0.05
0.05
0.95
0.95
0 (0.000)
0 (0.000)
11 (0.094)
16 (0.105)
106 (0.906)
136 (0.895)
rs2250090 (IDE_11) Sweden AD
CTR
0.03
0.03
0.97
0.97
1 (0.003)
0 (0.000)
21 (0.055)
10 (0.057)
360 (0.942)
166 (0.943)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2251101 (IDE_7) Scotland AD
CTR
0.28
0.32
0.72
0.68
10 (0.084)
18 (0.119)
47 (0.395)
61 (0.404)
62 (0.521)
72 (0.477)
rs2251101 (IDE_7) Sweden AD
CTR
0.24
0.23
0.76
0.77
18 (0.047)
8 (0.046)
145 (0.379)
65 (0.374)
220 (0.574)
101 (0.580)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2275218 (IDE_10) Scotland AD
CTR
0.04
0.04
0.96
0.96
2 (0.017)
2 (0.013)
6 (0.051)
8 (0.053)
109 (0.932)
140 (0.933)
rs2275218 (IDE_10) Sweden AD
CTR
0.07
0.09
0.93
0.91
4 (0.011)
5 (0.029)
47 (0.127)
21 (0.122)
320 (0.863)
146 (0.849)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs2421942 (IDE_15) Scotland AD
CTR
0.03
0.04
0.97
0.96
1 (0.008)
1 (0.007)
4 (0.034)
9 (0.059)
113 (0.958)
143 (0.935)
rs2421942 (IDE_15) Sweden AD
CTR
0.08
0.07
0.92
0.93
4 (0.010)
1 (0.006)
52 (0.135)
24 (0.136)
330 (0.855)
151 (0.858)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2421943 (IDE_17) Scotland AD
CTR
0.45
0.43
0.55
0.57
27 (0.227)
29 (0.191)
53 (0.445)
74 (0.487)
39 (0.328)
49 (0.322)
rs2421943 (IDE_17) Sweden AD
CTR
0.42
0.42
0.58
0.58
69 (0.181)
31 (0.178)
181 (0.474)
84 (0.483)
132 (0.346)
59 (0.339)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2421945 (IDE_19) Scotland AD
CTR
0.31
0.34
0.69
0.66
12 (0.103)
11 (0.073)
47 (0.405)
79 (0.527)
57 (0.491)
60 (0.400)
rs2421945 (IDE_19) Sweden AD
CTR
0.40
0.41
0.60
0.59
61 (0.161)
29 (0.167)
182 (0.480)
84 (0.483)
136 (0.359)
61 (0.351)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs551266 Scotland AD
CTR
0.18
0.23
0.82
0.77
3 (0.025)
7 (0.046)
38 (0.317)
56 (0.368)
79 (0.658)
89 (0.586)
rs551266 Sweden AD
CTR
0.17
0.17
0.83
0.83
9 (0.023)
3 (0.017)
117 (0.302)
52 (0.299)
261 (0.674)
119 (0.684)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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