AlzGene - Polymorphism Details
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 Study: Nowotny, 2005
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 17

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3758505 (IDE_1) UK I (mixed) AD
CTR		 0.08
0.08		 0.92
0.92		 0 (0.000)
3 (0.009)		 49 (0.155)
49 (0.151)		 268 (0.845)
272 (0.840)
rs3758505 (IDE_1) USA (WashU) AD
CTR		 0.07
0.07		 0.93
0.93		 2 (0.009)
4 (0.018)		 30 (0.128)
23 (0.101)		 203 (0.864)
201 (0.882)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs4646958 (IDE8) USA (WashU) AD
CTR		 0.09
0.09		 0.91
0.91		 3 (0.007)
3 (0.008)		 69 (0.164)
64 (0.165)		 348 (0.829)
321 (0.827)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1999764 (IDE_18) USA (WashU) AD
CTR		 0.08
0.09		 0.92
0.91		 3 (0.007)
3 (0.008)		 62 (0.148)
64 (0.165)		 355 (0.845)
321 (0.827)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1832196 (IDE_14) UK II (IAH) AD
CTR		 0.14
0.09		 0.86
0.91		 5 (0.031)
1 (0.009)		 34 (0.210)
18 (0.164)		 123 (0.759)
91 (0.827)
rs1832196 (IDE_14) UK I (mixed) AD
CTR		 0.14
0.15		 0.86
0.85		 5 (0.013)
6 (0.016)		 99 (0.263)
100 (0.260)		 272 (0.723)
278 (0.724)
rs1832196 (IDE_14) USA (UCSD) AD
CTR		 0.13
0.14		 0.87
0.86		 4 (0.017)
8 (0.023)		 53 (0.227)
82 (0.231)		 176 (0.755)
265 (0.746)
rs1832196 (IDE_14) USA (WashU) AD
CTR		 0.15
0.14		 0.85
0.86		 6 (0.015)
10 (0.026)		 115 (0.278)
85 (0.223)		 292 (0.707)
286 (0.751)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1887922 USA (WashU) AD
CTR		 0.18
0.17		 0.82
0.83		 14 (0.033)
11 (0.028)		 124 (0.295)
109 (0.282)		 282 (0.671)
267 (0.690)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2251101 (IDE_7) USA (UCSD) AD
CTR		 0.28
0.28		 0.72
0.72		 12 (0.051)
31 (0.087)		 108 (0.456)
137 (0.385)		 117 (0.494)
188 (0.528)
rs2251101 (IDE_7) UK I (mixed) AD
CTR		 0.25
0.31		 0.75
0.69		 22 (0.059)
46 (0.120)		 143 (0.381)
147 (0.384)		 210 (0.560)
190 (0.496)
rs2251101 (IDE_7) UK II (IAH) AD
CTR		 0.27
0.35		 0.73
0.65		 12 (0.073)
14 (0.120)		 64 (0.388)
55 (0.470)		 89 (0.539)
48 (0.410)
rs2251101 (IDE_7) USA (WashU) AD
CTR		 0.27
0.28		 0.73
0.72		 34 (0.082)
27 (0.071)		 159 (0.385)
162 (0.426)		 220 (0.533)
191 (0.503)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs17445028 (hCV1819799) USA (WashU) AD
CTR		 0.20
0.19		 0.80
0.81		 17 (0.040)
14 (0.036)		 134 (0.319)
119 (0.307)		 269 (0.640)
255 (0.657)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4646957 USA (WashU) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs7084090 USA (WashU) AD
CTR		 0.18
0.17		 0.82
0.83		 14 (0.033)
11 (0.028)		 124 (0.295)
109 (0.282)		 282 (0.671)
267 (0.690)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
rs7918084 USA (WashU) AD
CTR		 0.44
0.43		 0.56
0.57		 81 (0.193)
72 (0.186)		 207 (0.493)
190 (0.490)		 132 (0.314)
126 (0.325)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV11194331 USA (WashU) AD
CTR		 0.19
0.18		 0.81
0.82		 15 (0.036)
13 (0.033)		 129 (0.307)
115 (0.296)		 276 (0.657)
261 (0.671)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV11194366 USA (WashU) AD
CTR		 0.24
0.24		 0.76
0.76		 24 (0.057)
22 (0.057)		 153 (0.364)
142 (0.366)		 243 (0.579)
224 (0.577)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV115183 USA (WashU) AD
CTR		 0.27
0.27		 0.73
0.73		 31 (0.074)
28 (0.072)		 166 (0.394)
153 (0.394)		 224 (0.532)
207 (0.534)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV1819830 USA (WashU) AD
CTR		 0.37
0.37		 0.63
0.63		 57 (0.136)
53 (0.137)		 196 (0.467)
181 (0.466)		 167 (0.398)
154 (0.397)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV22272896 USA (WashU) AD
CTR		 0.19
0.19		 0.81
0.81		 15 (0.036)
14 (0.036)		 129 (0.307)
119 (0.307)		 276 (0.657)
255 (0.657)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   min-Allele maj-Allele min/min
(frequency)		 min/maj
(frequency)		 maj/maj
(frequency)
 Caucasian
hCV22273765 USA (WashU) AD
CTR		 0.38
0.37		 0.62
0.63		 61 (0.145)
53 (0.137)		 198 (0.471)
181 (0.466)		 161 (0.383)
154 (0.397)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7100623 USA (WashU) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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