AlzGene - Polymorphism Details
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 Study: Mueller, 2006
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 27

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3758505 (IDE_1) Germany AD
CTR		 0.11
0.08		 0.89
0.92		 6 (0.014)
2 (0.007)		 88 (0.198)
40 (0.149)		 350 (0.788)
227 (0.844)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs4646953 Germany AD
CTR		 0.21
0.19		 0.79
0.81		 20 (0.045)
10 (0.037)		 147 (0.331)
83 (0.309)		 277 (0.624)
176 (0.654)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4646954 Germany AD
CTR		 0.11
0.09		 0.89
0.91		 6 (0.014)
2 (0.007)		 89 (0.200)
42 (0.156)		 349 (0.786)
225 (0.836)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1999764 (IDE_18) Germany AD
CTR		 0.10
0.09		 0.90
0.91		 5 (0.011)
2 (0.007)		 83 (0.187)
42 (0.156)		 356 (0.802)
225 (0.836)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1832196 (IDE_14) Germany AD
CTR		 0.17
0.14		 0.83
0.86		 13 (0.029)
5 (0.019)		 125 (0.281)
65 (0.242)		 307 (0.690)
199 (0.740)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1832197 (IDE_16) Germany AD
CTR		 0.44
0.38		 0.56
0.62		 85 (0.191)
39 (0.146)		 218 (0.491)
127 (0.474)		 141 (0.318)
102 (0.381)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2149632 (IDE_12) Germany AD
CTR		 0.34
0.38		 0.66
0.62		 51 (0.115)
39 (0.145)		 199 (0.449)
127 (0.472)		 193 (0.436)
103 (0.383)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2251101 (IDE_7) Germany AD
CTR		 0.28
0.27		 0.72
0.73		 35 (0.079)
20 (0.074)		 179 (0.402)
106 (0.394)		 231 (0.519)
143 (0.532)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2421945 (IDE_19) Germany AD
CTR		 0.38
0.33		 0.62
0.67		 64 (0.144)
30 (0.112)		 209 (0.471)
120 (0.446)		 171 (0.385)
119 (0.442)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs551266 Germany AD
CTR		 0.19
0.16		 0.81
0.84		 17 (0.038)
7 (0.026)		 139 (0.313)
74 (0.275)		 288 (0.649)
188 (0.699)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs17445028 (hCV1819799) Germany AD
CTR		 0.20
0.19		 0.80
0.81		 18 (0.041)
10 (0.037)		 143 (0.322)
82 (0.305)		 283 (0.637)
177 (0.658)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs7084090 Germany AD
CTR		 0.21
0.17		 0.79
0.83		 19 (0.043)
8 (0.030)		 147 (0.331)
77 (0.286)		 278 (0.626)
184 (0.684)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
hCV27434720 Germany AD
CTR		 0.32
0.28		 0.68
0.72		 46 (0.103)
21 (0.078)		 194 (0.436)
108 (0.403)		 205 (0.461)
139 (0.519)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
hCV27434725 Germany AD
CTR		 0.18
0.16		 0.82
0.84		 15 (0.034)
7 (0.026)		 133 (0.300)
71 (0.263)		 296 (0.667)
192 (0.711)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10882066 Germany AD
CTR		 0.10
0.09		 0.90
0.91		 5 (0.011)
2 (0.007)		 81 (0.182)
44 (0.164)		 358 (0.806)
223 (0.829)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11187007 Germany AD
CTR		 0.35
0.39		 0.65
0.61		 54 (0.122)
41 (0.152)		 202 (0.455)
128 (0.476)		 188 (0.423)
100 (0.372)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11187032 Germany AD
CTR		 0.26
0.26		 0.74
0.74		 30 (0.068)
18 (0.067)		 170 (0.383)
103 (0.383)		 244 (0.550)
148 (0.550)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11187033 Germany AD
CTR		 0.34
0.39		 0.66
0.61		 51 (0.115)
40 (0.149)		 199 (0.448)
128 (0.476)		 194 (0.437)
101 (0.375)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs11187040 Germany AD
CTR		 0.20
0.15		 0.80
0.85		 18 (0.041)
6 (0.022)		 143 (0.322)
68 (0.253)		 283 (0.637)
195 (0.725)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs11187060 Germany AD
CTR		 0.37
0.32		 0.63
0.68		 60 (0.135)
27 (0.100)		 206 (0.464)
117 (0.435)		 178 (0.401)
125 (0.465)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11187064 Germany AD
CTR		 0.26
0.26		 0.74
0.74		 30 (0.068)
18 (0.067)		 170 (0.383)
103 (0.381)		 244 (0.550)
149 (0.552)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs12416180 Germany AD
CTR		 0.11
0.09		 0.89
0.91		 5 (0.011)
2 (0.007)		 88 (0.198)
42 (0.156)		 351 (0.791)
225 (0.836)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs12783634 Germany AD
CTR		 0.08
0.06		 0.92
0.94		 3 (0.007)
1 (0.004)		 62 (0.140)
31 (0.115)		 379 (0.854)
237 (0.881)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1999763 Germany AD
CTR		 0.11
0.09		 0.89
0.91		 6 (0.014)
2 (0.007)		 89 (0.200)
45 (0.167)		 349 (0.786)
222 (0.825)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2421940 Germany AD
CTR		 0.11
0.09		 0.89
0.91		 5 (0.011)
2 (0.007)		 84 (0.189)
45 (0.167)		 355 (0.800)
222 (0.825)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7076966 Germany AD
CTR		 0.41
0.49		 0.59
0.51		 76 (0.172)
65 (0.242)		 215 (0.485)
134 (0.498)		 152 (0.343)
70 (0.260)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7895832 Germany AD
CTR		 0.09
0.07		 0.91
0.93		 3 (0.007)
1 (0.004)		 71 (0.160)
35 (0.130)		 369 (0.833)
233 (0.866)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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