AlzGene - Polymorphism Details
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 Study: Feuk, 2005
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 9

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs3758505 (IDE_1) Scotland AD
CTR
0.10
0.08
0.90
0.92
0 (0.000)
2 (0.013)
24 (0.202)
20 (0.132)
95 (0.798)
129 (0.854)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4646953 Scotland AD
CTR
0.17
0.20
0.83
0.80
3 (0.025)
5 (0.034)
34 (0.288)
50 (0.340)
81 (0.686)
92 (0.626)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs4646954 Scotland AD
CTR
0.11
0.08
0.89
0.92
0 (0.000)
2 (0.013)
26 (0.226)
21 (0.141)
89 (0.774)
126 (0.846)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
rs4646958 (IDE8) Scotland AD
CTR
0.11
0.09
0.89
0.91
0 (0.000)
0 (0.000)
25 (0.223)
25 (0.170)
87 (0.777)
122 (0.830)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs4646957 Scotland AD
CTR
0.33
0.33
0.67
0.67
13 (0.113)
11 (0.073)
51 (0.443)
77 (0.510)
51 (0.443)
63 (0.417)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4646955 Scotland AD
CTR
0.22
0.25
0.78
0.75
6 (0.050)
7 (0.046)
40 (0.336)
61 (0.404)
73 (0.613)
83 (0.550)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
ss28525229 Scotland AD
CTR
0.03
0.03
0.97
0.97
1 (0.008)
1 (0.007)
4 (0.034)
8 (0.053)
114 (0.958)
142 (0.940)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
ss28525230 Scotland AD
CTR
0.09
0.10
0.91
0.90
1 (0.009)
1 (0.007)
18 (0.155)
28 (0.188)
97 (0.836)
120 (0.805)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
ss28525231 Scotland AD
CTR
0.00
0.01
1.00
0.99
0 (0.000)
1 (0.007)
1 (0.008)
1 (0.007)
118 (0.992)
148 (0.987)
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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