AlzGene - Polymorphism Details
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 Study: Szymanski, 2008
 Gene: HIF1A  (HIF1; MOP1; PASD8; bHLHe78; HIF-1alpha; HIF1-ALPHA)  Entrez Gene
 Protein: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)   ProteinLink
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 May 2009
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 5

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11846496 USA (NIMH, NCRAD) AD
CTR		 0.15
0.12		 0.85
0.88		 12 (0.055)
4 (0.027)		 43 (0.196)
27 (0.181)		 164 (0.749)
118 (0.792)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1319462 USA (NIMH, NCRAD) AD
CTR		 0.20
0.17		 0.80
0.83		 16 (0.073)
4 (0.027)		 55 (0.250)
42 (0.282)		 149 (0.677)
103 (0.691)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2256605 USA (NIMH, NCRAD) AD
CTR		 0.16
0.14		 0.84
0.86		 14 (0.064)
5 (0.034)		 42 (0.192)
31 (0.208)		 163 (0.744)
113 (0.758)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2301113 USA (NIMH, NCRAD) AD
CTR		 0.28
0.27		 0.72
0.73		 29 (0.133)
14 (0.094)		 66 (0.303)
52 (0.349)		 123 (0.564)
83 (0.557)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs798847 USA (NIMH, NCRAD) AD
CTR		 0.12
0.09		 0.88
0.91		 9 (0.041)
4 (0.027)		 35 (0.158)
20 (0.133)		 177 (0.801)
126 (0.840)
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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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