AlzGene - Polymorphism Details
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 Study: Goumidi, 2009
 Gene: THRA  (AR7; EAR7; ERBA; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; MGC43240; c-ERBA-1)  Entrez Gene
 Protein: thyroid hormone receptor, alpha  (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 5

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs868150 France (I) AD
CTR
0.40
0.42
0.60
0.58
111 (0.161)
105 (0.181)
335 (0.485)
279 (0.480)
245 (0.355)
197 (0.339)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs7502966 France (I) AD
CTR
0.45
0.44
0.55
0.56
149 (0.215)
115 (0.196)
330 (0.476)
283 (0.483)
214 (0.309)
188 (0.321)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1568400 France (I) AD
CTR
0.25
0.27
0.75
0.73
37 (0.053)
38 (0.066)
283 (0.403)
233 (0.403)
382 (0.544)
307 (0.531)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs939348 France (I) AD
CTR
0.26
0.25
0.74
0.75
45 (0.065)
24 (0.041)
273 (0.395)
248 (0.421)
374 (0.540)
317 (0.538)
rs939348 France (II) AD
CTR
0.30
0.26
0.70
0.74
47 (0.090)
31 (0.068)
219 (0.421)
175 (0.386)
254 (0.488)
247 (0.545)
rs939348 Italy AD
CTR
0.34
0.29
0.66
0.71
18 (0.119)
8 (0.087)
68 (0.450)
38 (0.413)
65 (0.430)
46 (0.500)
rs939348 UK AD
CTR
0.31
0.27
0.69
0.73
38 (0.098)
15 (0.073)
166 (0.430)
81 (0.395)
182 (0.472)
109 (0.532)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs3744805 France (I) AD
CTR
0.12
0.11
0.88
0.89
12 (0.017)
6 (0.010)
144 (0.203)
114 (0.191)
554 (0.780)
477 (0.799)
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Genes: 695
Polymorphisms: 2973
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