AlzGene - Polymorphism Details
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 Study: Golanska, 2009
 Gene: PRND  (DPL; PrPLP; DOPPEL; MGC41841; dJ1068H6.4)  Entrez Gene
 Protein: prion protein 2  (prion gene complex, downstream)  ProteinLink
 Chromosome: 20   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 26 January 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2245220 (M174T) Poland AD
CTR		 0.50
0.45		 0.50
0.55		 54 (0.260)
37 (0.218)		 101 (0.486)
78 (0.459)		 53 (0.255)
55 (0.324)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   Met-Allele Thr-Allele Met/Met
(frequency)		 Met/Thr
(frequency)		 Thr/Thr
(frequency)
 Caucasian
PRND_Thr26Met Poland AD
CTR		 0.07
0.07		 0.93
0.93		 1 (0.005)
0 (0.000)		 28 (0.131)
23 (0.135)		 184 (0.864)
148 (0.865)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   Leu-Allele Pro-Allele Leu/Leu
(frequency)		 Leu/Pro
(frequency)		 Pro/Pro
(frequency)
 Caucasian
PRND_Pro56Leu Poland AD
CTR		 0.01
0.02		 0.99
0.98		 0 (0.000)
0 (0.000)		 6 (0.028)
7 (0.041)		 207 (0.972)
164 (0.959)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
PRND_3'UTRC/T Poland AD
CTR		 0.50
0.45		 0.50
0.55		 55 (0.258)
39 (0.228)		 104 (0.488)
77 (0.450)		 54 (0.254)
55 (0.322)
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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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