AlzGene - Polymorphism Details
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 Study: Wang, 2010
 Gene: ADAM17  (ADAM18; CD156B; CSVP; MGC71942; TACE)  Entrez Gene
 Protein: ADAM metallopeptidase domain 17  (ADAM 17; ADAM metallopeptidase domain 18; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; disintegrin and metalloproteinase domain-containing protein 17; snake venom-like protease; tumor necrosis factor, alpha, converting enzyme)  ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 3 November 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Asian
rs11689958 (-1672C/T) China AD
CTR
0.02
0.02
0.98
0.98
0 (0.000)
0 (0.000)
18 (0.045)
12 (0.037)
385 (0.955)
311 (0.963)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Asian
rs1524668 (-1638T/G) China AD
CTR
0.07
0.07
0.93
0.93
3 (0.007)
0 (0.000)
51 (0.127)
44 (0.136)
349 (0.866)
279 (0.864)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs11684747 (-1437T/C) China AD
CTR
0.03
0.02
0.97
0.98
0 (0.000)
0 (0.000)
21 (0.052)
10 (0.031)
382 (0.948)
313 (0.969)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Asian
rs12474969 (-1333C/T) China AD
CTR
0.01
0.01
0.99
0.99
0 (0.000)
0 (0.000)
9 (0.022)
5 (0.015)
394 (0.978)
318 (0.985)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs12692386 (-172T/C) China AD
CTR
0.24
0.22
0.76
0.78
17 (0.042)
10 (0.031)
161 (0.400)
122 (0.378)
225 (0.558)
191 (0.591)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Asian
ADAM17_154C/A China AD
CTR
0.03
0.02
0.97
0.98
0 (0.000)
0 (0.000)
23 (0.057)
11 (0.034)
380 (0.943)
312 (0.966)
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