AlzGene - Polymorphism Details
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 Study: Wood, 2007
 Gene: MME  (NEP; CD10; CALLA)  Entrez Gene
 Protein: neprilysin  (membrane metallo-endopeptidase; neutral endopeptidase; enkephalinase)  ProteinLink
 Chromosome: 3   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 22

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   22-Allele non22-Allele 22/22
(frequency)		 22/non22
(frequency)		 non22/non22
(frequency)
 Caucasian
rs5853711 (-1784 (gt)p) USA AD
CTR		 0.05
0.05		 0.95
0.95		 1 (0.003)
1 (0.003)		 29 (0.097)
29 (0.097)		 268 (0.899)
268 (0.899)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs701109 (3'UTR159) USA AD
CTR		 0.34
0.36		 0.66
0.64		 35 (0.118)
45 (0.153)		 134 (0.453)
121 (0.412)		 127 (0.429)
128 (0.435)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs989692 USA AD
CTR		 0.43
0.48		 0.57
0.52		 56 (0.188)
66 (0.223)		 147 (0.493)
153 (0.517)		 95 (0.319)
77 (0.260)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2196521 USA AD
CTR		 0.09
0.12		 0.91
0.88		 1 (0.003)
5 (0.017)		 49 (0.164)
63 (0.211)		 248 (0.832)
230 (0.772)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1025192 USA AD
CTR		 0.57
0.54		 0.43
0.46		 90 (0.302)
88 (0.297)		 159 (0.534)
146 (0.493)		 49 (0.164)
62 (0.209)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1816558 USA AD
CTR		 0.28
0.29		 0.72
0.71		 21 (0.071)
26 (0.088)		 127 (0.428)
122 (0.412)		 149 (0.502)
148 (0.500)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs3773885 USA AD
CTR		 0.37
0.35		 0.63
0.65		 39 (0.131)
34 (0.114)		 141 (0.473)
138 (0.465)		 118 (0.396)
125 (0.421)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3736187 USA AD
CTR		 0.07
0.06		 0.93
0.94		 2 (0.007)
1 (0.003)		 40 (0.135)
34 (0.114)		 255 (0.859)
262 (0.882)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs10513467 USA AD
CTR		 0.05
0.05		 0.95
0.95		 0 (0.000)
1 (0.003)		 27 (0.091)
27 (0.091)		 270 (0.909)
270 (0.906)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs11925306 USA AD
CTR		 0.05
0.04		 0.95
0.96		 0 (0.000)
0 (0.000)		 27 (0.091)
25 (0.084)		 271 (0.909)
273 (0.916)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs13077421 USA AD
CTR		 0.09
0.08		 0.91
0.92		 3 (0.010)
3 (0.010)		 48 (0.161)
44 (0.149)		 247 (0.829)
249 (0.841)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs13081581 USA AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1385477 USA AD
CTR		 0.28
0.32		 0.72
0.68		 19 (0.064)
35 (0.118)		 130 (0.438)
120 (0.405)		 148 (0.498)
141 (0.476)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs16846960 USA AD
CTR		 0.39
0.43		 0.61
0.57		 43 (0.145)
56 (0.189)		 147 (0.497)
145 (0.488)		 106 (0.358)
96 (0.323)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1836915 USA AD
CTR		 0.15
0.14		 0.85
0.86		 11 (0.037)
1 (0.003)		 65 (0.219)
79 (0.268)		 221 (0.744)
215 (0.729)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4432598 USA AD
CTR		 0.02
0.03		 0.98
0.97		 0 (0.000)
0 (0.000)		 14 (0.047)
17 (0.057)		 283 (0.953)
281 (0.943)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs6776185 USA AD
CTR		 0.38
0.42		 0.62
0.58		 53 (0.178)
46 (0.156)		 122 (0.409)
157 (0.532)		 123 (0.413)
92 (0.312)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs6801319 USA AD
CTR		 0.40
0.37		 0.60
0.63		 41 (0.139)
49 (0.164)		 153 (0.517)
123 (0.413)		 102 (0.345)
126 (0.423)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs7623854 USA AD
CTR		 0.42
0.36		 0.58
0.64		 50 (0.168)
34 (0.115)		 148 (0.497)
147 (0.497)		 100 (0.336)
115 (0.389)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs9834487 USA AD
CTR		 0.12
0.10		 0.88
0.90		 3 (0.010)
4 (0.014)		 67 (0.225)
54 (0.182)		 228 (0.765)
238 (0.804)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs9853221 USA AD
CTR		 0.14
0.16		 0.86
0.84		 3 (0.010)
9 (0.030)		 78 (0.264)
77 (0.258)		 215 (0.726)
212 (0.711)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs9881879 USA AD
CTR		 0.26
0.29		 0.74
0.71		 17 (0.057)
30 (0.101)		 121 (0.407)
112 (0.377)		 159 (0.535)
155 (0.522)
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Genes: 695
Polymorphisms: 2973
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