AlzGene

AlzGene - Polymorphism Details

Study:

Helisalmi, 2004

Gene:

MME (NEP; CD10; CALLA)

Protein:

neprilysin (membrane metallo-endopeptidase; neutral endopeptidase; enkephalinase)

Chromosome:

3 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs989692	Finland	AD CTR	0.36 0.30	0.64 0.70	51 (0.131) 33 (0.070)	179 (0.459) 211 (0.450)	160 (0.410) 225 (0.480)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs2196521	Finland	AD CTR	0.14 0.13	0.86 0.88	12 (0.031) 14 (0.030)	86 (0.220) 89 (0.190)	293 (0.749) 365 (0.780)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1025192	Finland	AD CTR	0.48 0.48	0.52 0.52	90 (0.231) 108 (0.231)	191 (0.490) 229 (0.489)	109 (0.279) 131 (0.280)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs1816558	Finland	AD CTR	0.39 0.41	0.61 0.59	66 (0.169) 84 (0.179)	172 (0.441) 215 (0.459)	152 (0.390) 169 (0.361)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs3773885	Finland	AD CTR	0.33 0.32	0.67 0.68	47 (0.121) 47 (0.100)	160 (0.410) 206 (0.440)	183 (0.469) 215 (0.459)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs3773882	Finland	AD CTR	0.22 0.23	0.78 0.77	20 (0.051) 19 (0.041)	133 (0.340) 173 (0.370)	238 (0.609) 276 (0.590)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs3736187	Finland	AD CTR	0.14 0.18	0.86 0.82	4 (0.010) 14 (0.030)	98 (0.251) 145 (0.310)	289 (0.739) 309 (0.660)

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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