AlzGene - Polymorphism Details
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 Study: Chu, 2007
 Gene: ABCA1  (TGD; ABC1; CERP; ABC-1; HDLDT1)  Entrez Gene
 Protein: ATP-binding cassette, sub-family A member 1  (ATP binding cassette transporter 1; cholesterol efflux regulatory protein; high density lipoprotein deficiency, Tangier type, 1; ATP-binding cassette 1)  ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 19

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Asian
rs2230808 (R1587K) China AD
CTR
0.49
0.42
0.51
0.58
62 (0.229)
44 (0.158)
140 (0.517)
146 (0.525)
69 (0.255)
88 (0.317)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Asian
rs2066714 (I883M) China AD
CTR
0.69
0.70
0.31
0.30
65 (0.478)
55 (0.487)
57 (0.419)
48 (0.425)
14 (0.103)
10 (0.088)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Asian
rs2230806 (R219K) China AD
CTR
0.32
0.34
0.68
0.66
13 (0.107)
15 (0.142)
52 (0.430)
43 (0.406)
56 (0.463)
48 (0.453)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Asian
rs1929841 China AD
CTR
0.28
0.24
0.72
0.76
9 (0.069)
10 (0.089)
54 (0.415)
34 (0.304)
67 (0.515)
68 (0.607)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Asian
rs2020926 China AD
CTR
0.32
0.29
0.68
0.71
14 (0.106)
14 (0.126)
57 (0.432)
36 (0.324)
61 (0.462)
61 (0.550)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Asian
rs2254884 China AD
CTR
0.39
0.43
0.61
0.57
20 (0.150)
20 (0.189)
65 (0.489)
51 (0.481)
48 (0.361)
35 (0.330)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Asian
rs2297402 China AD
CTR
0.08
0.07
0.92
0.93
2 (0.015)
0 (0.000)
18 (0.134)
15 (0.133)
114 (0.851)
98 (0.867)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Asian
rs2472384 China AD
CTR
0.28
0.34
0.72
0.66
11 (0.106)
15 (0.152)
36 (0.346)
37 (0.374)
57 (0.548)
47 (0.475)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Asian
rs2487039 China AD
CTR
0.24
0.25
0.76
0.75
8 (0.061)
7 (0.063)
47 (0.359)
43 (0.384)
76 (0.580)
62 (0.554)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Asian
rs2575875 China AD
CTR
0.36
0.32
0.64
0.68
17 (0.126)
14 (0.124)
62 (0.459)
45 (0.398)
56 (0.415)
54 (0.478)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Asian
rs2575876 China AD
CTR
0.28
0.19
0.72
0.81
13 (0.099)
5 (0.046)
48 (0.366)
31 (0.287)
70 (0.534)
72 (0.667)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Asian
rs2575879 China AD
CTR
0.24
0.19
0.76
0.81
7 (0.053)
7 (0.064)
48 (0.366)
28 (0.257)
76 (0.580)
74 (0.679)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele A-Allele C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
 Asian
rs3858074 China AD
CTR
0.26
0.27
0.74
0.73
10 (0.078)
12 (0.112)
48 (0.372)
34 (0.318)
71 (0.550)
61 (0.570)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs4149263 China AD
CTR
0.13
0.18
0.87
0.82
4 (0.029)
2 (0.018)
28 (0.206)
37 (0.333)
104 (0.765)
72 (0.649)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Asian
rs4149264 China AD
CTR
0.13
0.17
0.87
0.83
4 (0.029)
2 (0.019)
28 (0.206)
33 (0.308)
104 (0.765)
72 (0.673)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs4149265 China AD
CTR
0.52
0.46
0.48
0.54
35 (0.263)
28 (0.248)
67 (0.504)
49 (0.434)
31 (0.233)
36 (0.319)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs2777793 China AD
CTR
0.27
0.30
0.73
0.70
12 (0.089)
10 (0.095)
49 (0.363)
42 (0.400)
74 (0.548)
53 (0.505)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Asian
rs2020927 China AD
CTR
0.49
0.43
0.51
0.57
61 (0.227)
42 (0.154)
141 (0.524)
149 (0.548)
67 (0.249)
81 (0.298)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Asian
rs2297404 China AD
CTR
0.33
0.26
0.67
0.74
26 (0.096)
16 (0.061)
124 (0.459)
106 (0.402)
120 (0.444)
142 (0.538)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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