AlzGene

AlzGene - Polymorphism Details

Study:

Shibata, 2005

Gene:

ABCA1 (TGD; ABC1; CERP; ABC-1; HDLDT1)

Protein:

ATP-binding cassette, sub-family A member 1 (ATP binding cassette transporter 1; cholesterol efflux regulatory protein; high density lipoprotein deficiency, Tangier type, 1; ATP-binding cassette 1)

Chromosome:

9 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2230808 (R1587K)	USA, Canada	AD CTR	0.17 0.18	0.83 0.82	6 (0.028) 6 (0.031)	62 (0.284) 58 (0.297)	150 (0.688) 131 (0.672)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs2066714 (I883M)	USA, Canada	AD CTR	0.29 0.26	0.71 0.74	18 (0.083) 13 (0.067)	90 (0.413) 75 (0.385)	110 (0.505) 107 (0.549)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2230806 (R219K)	USA, Canada	AD CTR	0.26 0.22	0.74 0.78	15 (0.069) 9 (0.046)	84 (0.385) 67 (0.344)	119 (0.546) 119 (0.610)

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs2422493 (C-477T)	USA, Canada	AD CTR	0.44 0.45	0.56 0.55	42 (0.194) 39 (0.200)	107 (0.493) 97 (0.497)	68 (0.313) 59 (0.303)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Hispanic
rs2230808 (R1587K)	Mixed	AD CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Hispanic
rs2066714 (I883M)	Mixed	AD CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Hispanic
rs2230806 (R219K)	Mixed	AD CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Hispanic
rs2422493 (C-477T)	Mixed	AD CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

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