AlzGene

AlzGene - Polymorphism Details

Study:

Jamieson, 2004

Gene:

SLC11A1 (LSH; NRAMP1; NRAMP)

View on MSGene

Protein:

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (natural resistance-associated macrophage protein 1; solute carrier family 11 (sodium/phosphate symporters), member 1; natural resistance-associated macrophage protein 1 (might include Leishmaniasis))

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 10 February 2005

Total number of polymorphisms investigated by this study: 3

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	G-Allele	C/C (frequency)	C/G (frequency)	G/G (frequency)
Caucasian
rs3731865 (469-14 G/C)	UK	AD CTR	0.27 0.29	0.73 0.71	11 (0.054) 22 (0.075)	89 (0.438) 124 (0.422)	103 (0.507) 148 (0.503)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs2279015 (1465-85 A/G)	UK	AD CTR	0.37 0.40	0.63 0.60	27 (0.158) 41 (0.166)	73 (0.427) 117 (0.474)	71 (0.415) 89 (0.360)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs2276631 (274 C/T)	UK	AD CTR	0.27 0.28	0.73 0.72	12 (0.059) 22 (0.071)	85 (0.415) 131 (0.420)	108 (0.527) 159 (0.510)

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.

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An up-to-date collection of all published genetic association studies.