AlzGene - Overview of all published large-scale and genome-wide association studies in AD
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 Status: Updated 18 April 2011;  ** See Large Scale Study Methods **
GWAS (genome-wide association studies)
              AD Cases Normal Controls    
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)		 # Subjects
(follow-up)		 # Subjects
(GWAS)		 # Subjects
(follow-up)		 Featured Genes Comment
 Caucasian
Abraham, 2008
CCGWAS (pooled) Overlaps with
Harold, 2009		 CL Illumina (300K + 240K)561,494 No C1082-12391400
Beecham, 2009
CCGWAS USA (CAP)   Illumina (550K)532,000 No M492238496220
Bertram, 2008
FBATGWAS USA (NIMH) CL Affymetrix (500K)484,522 No M9411767404838
Carrasquillo, 2009
CCGWAS USA (Mayo) CL Illumina (300K)313,504 No M844154712551209
Coon, 2007
CCGWAS USA, Netherlands (TGEN1) CL Affymetrix (500K)502,627 No N664-422-
Grupe, 2007
CCGWAS USA & UK CL Celera (cSNPs)17,343 No M38014283961666
Harold, 2009
* Recently Updated *		CCGWAS Europe & USA (GERAD1) CL,PO Illumina (various)529,205 No M3941202378482340
Heinzen, 2009
CCGWAS+CNV USA (CAP, DUKE) CL Illumina (550K)n.g. No U331-368-
Hollingworth, 2011
* Recently Updated *		CCGWAS Europe & USA (GERAD1+2, EADI1+2, ADNI, TGEN1, MAYO2, CHARGE) CL,PO Various496,763 No M6688131821368526261
Hu, 2011
* Recently Updated *		CCGWAS USA (Pfizer, ADNI), Canada (GenADA, Genizon) CL Illumina (550K/610K)509,376 No C18317511764751
Lambert, 2009
* Recently Updated *		CCGWAS Europe (EADI1) CL Illumina (610K)537,029 No C2032397853283297
Li, 2008
* Recently Updated *		CCGWAS Canada (GenADA) CL Affymetrix (500K)469,438 Yes C753418736249
Naj, 2011
* Recently Updated *		CCGWAS USA (ADGC) CL Various2,324,889 (imputed) No M8309353173663565
Poduslo, 2009
CC, FBATGWAS USA CL Affymetrix (500K)489,218 No C919910225
Potkin, 2009
CC, QTGWAS USA (ADNI) CL Illumina (610K)516,645 Yes C172-209-
Reiman, 2007
* Recently Updated *		CCGWAS USA, Netherlands (TGEN1) CL Affymetrix (500K)312,316 Yes M446415290260
Seshadri, 2010
* Recently Updated *		CCGWAS + meta-analysis Europe & USA (CHARGE, EADI1, GERAD1) CL,PO Various2,540,000 (imputed) No M300665052260413532
Sherva, 2011
* Recently Added *		CCGWAS Israel (Wadi Ara) CO Illumina (300K, CNV370)2,540,000 (imputed) No C124-142-
Wijsman, 2011
* Recently Updated *		CC, FBATGWAS USA (NIA, NCRAD) CL Illumina (610K)565,336 Yes M18486171991573
 Other/Mixed
Lee, 2011
* Recently Updated *		CCGWAS USA (WHICAP, EFIGA, NIA, NCRAD) CL,PO Illumina (650Y)627,380 No C54924495441390
Naj, 2010
CCGWAS USA (CAP, NCRAD) CL Illumina (multiple)483,399 No M931133811042003
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Other large-scale studies
              AD Cases Normal Controls    
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)		 # Subjects
(follow-up)		 # Subjects
(GWAS)		 # Subjects
(follow-up)		 Featured Genes Comment
 Caucasian
Chapuis, 2009
CCOther France, USA, UK CL,PO Custom1156 No C50716944387393
Furney, 2010
* Recently Updated *		QTGWAS (MRI) Europe (AddNeuroMed), USA (ADNI) CL Illumina (610K)478,081 No C245-718-
Giedraitis, 2009
CCCandidate genes Sweden (ULSAM) CL Custom2578 Yes C86-404598
Grupe, 2006
CCChr. 10 Overlaps with
Grupe, 2007		 CL Celera (cSNPs)1,412 No M42213743821386
Han, 2010
* Recently Added *		QTGWAS (CSF) USA (ADNI) CL Illumina (610K)498,205 Yes C176-234-
Jones, 2010
* Recently Added *		CCGWAS (re-analysis) Europe & USA (EADI1, GERAD1) CL See primary studiesn.g. No M----
Kim, 2011
* Recently Added *		QTGWAS (CSF-QT) USA (ADNI) CL Illumina (610K)322,557 Yes C96-278-
Lambert, 2010
* Recently Added *		CCGWAS (re-analysis) Europe (EADI1) CL See primary study537,029 No C----
Lee, 2008
CC, FBATGWL+GWAS USA (NIA) CL Illumina (Linkage-IVb)5616 Yes M776-1109-
Li, 2006
CCChr. 9 Overlaps with
Grupe, 2007		 CL Celera (cSNPs)674 No M41916713772064
Li, 2008
CCOther (pooled) USA & UK CL Celera (cSNPs)4692 No C38016323962156
Liang, 2009
CC, FBATChr. 10 USA CL Custom667 No M5061521558974
Morgan, 2008
CCChr. 10 (pooled) UK (MRC) CL Custom528 No C36610013661001
Nalls, 2009
CCROH mapping Same as Reiman, 2007 CL See primary studyn.g. Yes M837-550-
Shen, 2010
* Recently Added *		QTGWAS (MRI) USA (ADNI) CL Illumina (610K)530,992 Yes C175-558-
Thornton-Wells, 2008
CC, FBATOther USA (CAP, NIMH, IU) CL Custom148 No M1873-1443-
Zubenko, 1998
CCGWAS (STR, pooled) USA CL CHLC Weber v6391 No N50505050
Zuchner, 2008
CCChr. 9 USA (CAP, NIMH, IU) CL Custom80 No M1454-928-
 Asian
Kuwano, 2006
CCChr. 10 fine-mapping Japan CL Custom1206 No C363336337372
Miyashita, 2007
CCChr. 10 fine-mapping Re-analysis of Kuwano, 2006 CL Custom1140 No C363336337372
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Design: “CC” (case-control), “FBAT” (family-based)
Type: “GWAS” (genome-wide association study); “Chromosome #” (chromosome-wide association study); “Other” (other large-scale association study); “cSNP” (coding-region SNP); "pooled" (large-scale association study based on pooled genotyping)
Source: Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
Platform: Please refer to orignal publication for exact description.
# SNPs: Approximate number of polymorphisms covered.
Onset Age and Age: Mean or median age at onset or examination, respectively.
DX: Criteria used to determine AD diagnosis -> "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Featured Genes: Dropdown menu of genes highlighted (“featured”) in original publication as potential AD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples. Markers in linkage-disequilibrium with APOE ε2/3/4 (e.g. variants located in APOC1, APOC2, PVRL2, or TOMM40) are summarized as "APOE" in this list. For more details, see APOE Methods .
(-) : No information provided.
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.