AlzGene - Gene overview of all published AD-association studies for APOE_e2/3/4
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 Gene: APOE_e2/3/4  (AD2 (ε2/3/4); MGC1571 (ε2/3/4); APOE (ε2/3/4))  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: apolipoprotein E (ε2/3/4)  (Alzheimer disease 2 (ε2/3/4))  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010 ;  ** See APOE Methods **
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Benjamin, 1995
UK CL  1  (detail)  45
(-)
N-80.9 + 6.1
(-)
46
(-)
75.1 + 9.6
(-)
Positive
Benjamin, 1996
Norway CL  1  (detail)  52
(-)
N-85.5 + 5.9
(-)
16
(-)
84.1 + 7.9
(-)
Positive
Betard, 1994
Canada CL  1  (detail)  258
(-)
N71.3 + 6.6
(-)
-97
(44%)
69.5 + 2.9
(64-75)
Positive
Chartier-Harlin, 1994
UK CL  1  (detail)  34
(-)
C57 + 5
(49-64)
-36
(-)
55 + 7.5
(-)
Positive
Chartier-Harlin, 1994
France CL  1  (detail)  36
(-)
C78 + 9
(65-91)
-38
(-)
80 + 8
(-)
Positive
Corder, 1994
Unknown CL  1  (detail)  115
(60%)
U71.5 + 7.2
(60-90)
-152
(57%)
70.3 + 5.3
(60-86)
Positive
Frisoni, 1994
Italy CL  1  (detail)  93
(-)
C-73.6 + 8.2
(-)
51
(-)
69.2 + 3.6
(-)
Positive
Galasko, 1994
Unknown    1  (detail)  74
(62%)
N-76.9 + 8.7
(-)
1000
(-)
-Positive
Gearing, 1995
USA CL  1  (detail)  100
(49%)
N-76.3
(54-93)
76
(18%)
67.1
(54-93)
Positive
Harrington, 1994
Europe (mixed) CL  1  (detail)  67
(60%)
N-77.8 + 10.2
(55-99)
58
(52%)
78.1 + 7.7
(60-91)
Positive
Kukull, 1996
USA CL  1  (detail)  234
(63%)
M76.6 + 6.9
(-)
80.2 + 6.8
(-)
304
(61%)
78.8 + 6.7
(-)
Positive
Kuusisto, 1994
Finland PO  1  (detail)  46
(70%)
C--911
(-)
-Positive
Lehtimaki, 1995
Finland CL  1  (detail)  83
(53%)
C-68.8 + 4.9
(-)
164
(58%)
63.2 + 10
(-)
Positive
Lehtovirta, 1995
Finland CL  1  (detail)  202
(71%)
M-75.4 + 8.5
(-)
55
(-)
-Positive
Lucotte, 1994
France CL  1  (detail)  93
(-)
C-68.9 + 8.3
(-)
498
(-)
37.1 + 10
(-)
Positive
Maestre, 1995
USA CO  1  (detail)  43
(-)
M-71 + 9.9
(-)
59
(-)
70 + 11.6
(-)
Positive
Martins, 1995
Australia CL  1  (detail)  142
(-)
C-76.9
(48-92)
79
(-)
72
(50-87)
Positive
Nalbantoglu, 1994
Canada CL  1  (detail)  113
(48%)
N-76.4 + 9.3
(-)
77
(31%)
70.1 + 15.2
(-)
Positive
Pickering-Brown, 1994
Unknown    1  (detail)  45
(-)
N--35
(-)
-Positive
Poirier, 1993
Canada CL  1  (detail)  91
(67%)
C-75.1 + 10.3
(-)
74
(61%)
75.8 + 9.6
(-)
Positive
Rebeck, 1993
USA CL  1  (detail)  39
(-)
N-79 + 10
(52-93)
35
(-)
69 + 18
(24-103)
Positive
Smith, 1994
UK CL  1  (detail)  58
(-)
M-77 + 8
(-)
74
(-)
71 + 10.6
(-)
Positive
Sorbi, 1994
Italy CL  1  (detail)  168
(-)
U56.7 + 4.2
(-)
-189
(-)
50.5 + 7.1
(-)
Positive
St Clair, 1995
Scotland CL  1  (detail)  153
(69%)
M67.7
(-)
-47
(38%)
78
(67-91)
Positive
Talbot, 1994
USA CL  1  (detail)  93
(-)
U-75 + 8
(-)
67
(-)
77 + 10
(-)
Positive
Tsai, 1994
USA CO  1  (detail)  77
(74%)
M78.7
(47-95)
80.5 + 8.9
(-)
77
(74%)
80 + 9.1
(-)
Positive
van Duijn, 1994
Netherlands PO  1  (detail)  175
(66%)
C57 + 5
(34-65)
63 + 4.4
(-)
532
(57%)
63 + 4.3
(-)
Positive
Zubenko, 1994
USA CL  1  (detail)  91
(62%)
M-76.1 + 7.8
(-)
61
(57%)
60.4 + 11.7
(-)
Positive
 African Descent
Hendrie, 1995
USA & Africa CO  1  (detail)  31
(61%)
C-82.7 + 5.3
(-)
54
(-)
78.2 + 6.1
(-)
Positive
Maestre, 1995
USA CO  1  (detail)  41
(-)
M-76 + 8.8
(-)
57
(-)
74 + 5.8
(-)
Positive
 Asian
Kawamata, 1994
Japan CL  1  (detail)  53
(-)
C72.6 + 6.7
(-)
-49
(-)
57.1 + 18.4
(26-90)
Positive
Noguchi, 1993
Japan    1  (detail)  38
(-)
U--584
(-)
-Positive
Okuizumi, 1994
Japan CL  1  (detail)  44
(-)
M--38
(-)
-Positive
Ueki, 1993
Japan CL  1  (detail)  42
(-)
C-75.6 + 7.8
(53-88)
96
(-)
72.1 + 9.9
(37-92)
Positive
Yoshizawa, 1994
Japan CL  1  (detail)  83
(78%)
M65.9 + 6
(-)
-608
(-)
47.6 + 7.8
(-)
Positive
 Hispanic
Maestre, 1995
USA CO  1  (detail)  61
(-)
M-76 + 9.4
(-)
90
(-)
74 + 7.1
(-)
Positive
 Other/Mixed
Fallin, 1997
USA CL,PO  1  (detail)  117
(59%)
C74 + 7
(-)
-228
(66%)
72.7 + 6.9
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Other/Mixed
Blacker, 1997
USA  1  (detail)  310697
(-)
M71.5 + 8.7
(42-93)
-231
(-)
69.1 + 12.2
(31-93)
Positive
Corder, 1994
USA  1  (detail)  66150
(63%)
M70.8 + 6.3
(60-91)
-197
(56%)
71.4 + 7.8
(60-92)
Positive
Farrer, 1995
USA & Europe  1  (detail)   549
(-)
M80.8 + 0.4
(-)
-3683
(-)
-Positive
Houlden, 1994
Unknown  1  (detail)  3562
(-)
U72 + 1.4
(-)
-46
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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