AlzGene - Gene overview of all published AD-association studies for CD33
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 Gene: CD33  (p67; SIGLEC3; FLJ00391; SIGLEC-3)  Entrez Gene
 Protein: CD33   ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bettens, 2009
Belgium CL  1  (detail)  1078
(66%)
M74.3 + 8.6
(-)
-652
(58%)
62.7 + 15.7
(-)
Negative
Harold, 2009
GWAS (Stage 1) CL  1  (detail)  3941
(63%)
M72.7
(-)
79
(-)
7848
(53%)
55.6
(-)
Negative
Hollingworth, 2011
* Recently Updated *
GWAS (EADI1) CL  1  (detail)  2025
(66%)
C66
(-)
68.3
(-)
5328
(61%)
73.8
(-)
Positive
Hollingworth, 2011
* Recently Updated *
GWAS (GERAD1) CL  1  (detail)  3941
(63%)
M73.2
(-)
78.6
(-)
7848
(66%)
55.6
(-)
Positive
Hollingworth, 2011
* Recently Updated *
REP (deCODE) CL  1  (detail)  925
(66%)
C--612
(61%)
-Positive
Naj, 2011
* Recently Updated *
USA (ADGC-GWAS) CL  1  (detail)  8309
(61%)
M--7366
(58%)
-Positive
Naj, 2011
* Recently Updated *
USA (ADGC-REP) CL  1  (detail)  3531
(60%)
M--3565
(61%)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bertram, 2008
USA (NIMH)  1  (detail)  410941
(69%)
M72.3 + 7.7
(50-97)
-404
(58%)
70 + 10.7
(31-93)
Positive
Bertram, 2008
USA (NIA)  1  (detail)  329748
(64%)
M74.2 + 7.1
(52-98)
-282
(59%)
73.4 + 9.6
(36-94)
Positive
Bertram, 2008
USA (NCRAD)  1  (detail)  331799
(66%)
M71.3 + 7.6
(50-98)
-293
(55%)
70.6 + 8.1
(39-93)
Negative
Bertram, 2008
USA (CAG)  1  (detail)  215220
(58%)
M69.3 + 9
(50-89)
-263
(63%)
73.3 + 8.6
(50-92)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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NCRAD

The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.