AlzGene - Gene overview of all published AD-association studies for CR1
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 Gene: CR1  (C3BR; C4BR; CD35; KN)  Entrez Gene    View on PDGene
 Protein: complement component (3b/4b) receptor 1 (Knops blood group)  (C3-binding protein; C3b/C4b receptor; CD35 antigen; Knops blood group antigen; complement component receptor 1; complement receptor 1)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Biffi, 2010
Overlaps with
Jun, 2010 (ADGC-C)
CL  1  (detail)  168
(52%)
C-75.5 + 7.7
(-)
215
(55%)
75.9 + 5.5
(-)
n.a.
Carrasquillo, 2010
* Recently Updated *
Overlaps with
Hollingworth, 2011 (Mayo)
CL  1  (detail)  1829
(-)
M--2576
(-)
-n.a.
Corneveaux, 2010
Overlaps with
Jun, 2010
CL  1  (detail)  1019
(64%)
N--591
(48%)
-Positive
Harold, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (GERAD1)
CL,PO  1  (detail)  1159
(58%)
M73.5
(-)
80.7
(-)
1783
(56%)
68.1
(-)
n.a.
Harold, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (GERAD1)
CL,PO  1  (detail)  555
(64%)
C70.5
(-)
72.9
(-)
824
(51%)
56.5
(-)
n.a.
Harold, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (Mayo)
CL,PO  1  (detail)  2227
(65%)
M72.9
(-)
79.7
(-)
5241
(53%)
51.2
(-)
n.a.
Hollingworth, 2011
* Recently Added *
Overlaps with
Naj, 2011 (ADNI)
CL  1  (detail)  151
(47%)
C73.5
(-)
76.6
(-)
177
(45%)
78
(-)
n.a.
Hollingworth, 2011
* Recently Added *
GWAS (EADI1) CL  1  (detail)  2025
(66%)
C66
(-)
68.3
(-)
5328
(61%)
73.8
(-)
Positive
Hollingworth, 2011
* Recently Added *
GWAS (GERAD1) CL  1  (detail)  3941
(63%)
M73.2
(-)
78.6
(-)
7848
(66%)
55.6
(-)
Positive
Hollingworth, 2011
* Recently Added *
Overlaps with
Naj, 2011 (TGEN)
CL  1  (detail)  571
(52%)
M-81
(-)
332
(63%)
80
(-)
Positive
Hollingworth, 2011
* Recently Added *
REP (AD-IG) CL  1  (detail)  709
(56%)
C69.5
(-)
72.8
(-)
971
(48%)
47.9
(-)
Positive
Hollingworth, 2011
* Recently Added *
REP (deCODE) CL  1  (detail)  925
(66%)
C--612
(61%)
-Positive
Hollingworth, 2011
* Recently Added *
REP (GERAD2) CL  1  (detail)  3262
(64%)
M72.9
(-)
77.7
(-)
3320
(56%)
73.7
(-)
Positive
Hu, 2011
* Recently Added *
USA (Pfizer-GWAS) CL  1  (detail)  733
(-)
C--792
(-)
-Positive
Hu, 2011
* Recently Added *
Overlaps with
Naj, 2011 (GenADA)
CL  1  (detail)  798
(-)
C--776
(-)
-n.a.
Hu, 2011
* Recently Added *
Overlaps with
Naj, 2011 (ADNI)
CL  1  (detail)  300
(-)
C--196
(-)
-Positive
Jun, 2010
Overlaps with
Naj, 2011
CL  3  (detail)  5935
(-)
M--7034
(-)
-n.a.
Kamboh, 2010
* Recently Updated *
Overlaps with
Naj, 2011
CL  2  (detail)  1348
(66%)
M72.6 + 6.4
(-)
-1359
(61%)
74.7 + 6.5
(-)
n.a.
Lambert, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (EADI1)
CL  2  (detail)  2025
(66%)
C68.3 + 9
(-)
73.7 + 8.9
(-)
5328
(61%)
73.8 + 5.4
(-)
n.a.
Lambert, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (GERAD2)
CL  2  (detail)  1084
(66%)
C74.4 + 8.6
(-)
78.6 + 8.1
(-)
509
(58%)
67 + 12.9
(-)
n.a.
Lambert, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (EADI2)
CL  2  (detail)  619
(67%)
C71.4 + 7.5
(-)
71.4 + 7.5
(-)
664
(60%)
69.2 + 6
(-)
n.a.
Lambert, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (EADI2)
CL  2  (detail)  1520
(68%)
C73.8 + 8.8
(-)
76.6 + 8.7
(-)
1291
(55%)
72.3 + 8.9
(-)
n.a.
Lambert, 2009
* Recently Updated *
Overlaps with
Hollingworth, 2011 (EADI2)
CL  2  (detail)  755
(57%)
C72.5 + 9.4
(-)
75.3 + 9.3
(-)
833
(62%)
76.9 + 10.9
(-)
n.a.
Li, 2008
Overlaps with
Naj, 2011 (GenADA)
CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
n.a.
Naj, 2011
* Recently Added *
USA (ADGC-GWAS) CL  2  (detail)  8309
(61%)
M--7366
(58%)
-Positive
Naj, 2011
* Recently Added *
USA (ADGC-REP) CL  2  (detail)  3531
(60%)
M--3565
(61%)
-Positive
Reiman, 2007
Overlaps with
Naj, 2011 (TGEN)
CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
n.a.
Seshadri, 2010
Europe (CHARGE; GWAS) CL  13  (detail)  1367
(-)
M--20866
(-)
-Trend
 African Descent
Jun, 2010
USA (ADGC-AA) CL  3  (detail)  462
(-)
M--449
(-)
-Negative
 Asian
Zhang, 2010
China CL  2  (detail)  254
(54%)
C72.6 + 6.8
(-)
78.4 + 6.7
(-)
357
(55%)
78.7 + 6.4
(-)
Positive
 Hispanic
Jun, 2010
USA (ADGC-H) CL  3  (detail)  549
(-)
M--544
(-)
-Negative
 Other/Mixed
Jun, 2010
Israel (ADGC-Wadi Ara) CL  3  (detail)  124
(-)
M--142
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Wijsman, 2011
* Recently Added *
Overlaps with
Naj, 2011
 2  (detail)  6111848
(-)
M--1991
(-)
-n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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