AlzGene - Gene overview of all published AD-association studies for PICALM
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 Gene: PICALM  (CALM; CLTH; LAP)  Entrez Gene    View on PDGene   View on SZGene
 Protein: phosphatidylinositol binding clathrin assembly protein  (clathrin assembly lymphoid-myeloid leukemia; phosphatidylinositol-binding clathrin assembly protein)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Biffi, 2010
Overlaps with
Jun, 2010
CL  1  (detail)  168
(52%)
C-75.5 + 7.7
(-)
215
(55%)
75.9 + 5.5
(-)
n.a.
Carrasquillo, 2010
USA CL  1  (detail)  1829
(-)
M--2576
(-)
-Positive
Corneveaux, 2010
* Recently Updated *
Overlaps with
Jun, 2010
CL  1  (detail)  1019
(64%)
N--591
(48%)
-n.a.
Furney, 2010
* Recently Added *
Overlaps with
Naj, 2011 (ADNI)
CL  6  (detail)  245
(52%)
C-75.3
(-)
284
(49%)
74.9
(-)
n.a.
Harold, 2009
Stage 2 (Belgium) CL  1  (detail)  1091
(66%)
M74.4
(-)
78.6
(-)
662
(58%)
63
(-)
Positive
Harold, 2009
Stage 2 (UK, Ireland) CL  1  (detail)  198
(79%)
C76.2
(-)
81.7
(-)
372
(64%)
76.6
(-)
Positive
Harold, 2009
Stage 2 (UK-ART) CL  1  (detail)  82
(79%)
C73.7
(-)
78
(-)
305
(68%)
74
(-)
Positive
Harold, 2009
Stage 2 (Germany) CL  1  (detail)  248
(65%)
C69.4
(-)
75.7
(-)
618
(66%)
79.6
(-)
Positive
Harold, 2009
Stage 2 (Greece) CL  1  (detail)  404
(65%)
C69
(-)
76.7
(-)
383
(38%)
54.9
(-)
Positive
Harold, 2009
Stage 1 (USA) CL,PO  2  (detail)  1159
(58%)
M73.5
(-)
80.7
(-)
1783
(56%)
68.1
(-)
Positive
Harold, 2009
Stage 1 (Germany) CL,PO  2  (detail)  555
(64%)
C70.5
(-)
72.9
(-)
824
(51%)
56.5
(-)
Positive
Harold, 2009
Stage 1 (UK, Ireland) CL,PO  2  (detail)  2227
(65%)
M72.9
(-)
79.7
(-)
5241
(53%)
51.2
(-)
Positive
Hu, 2011
* Recently Added *
USA (Pfizer-GWAS) CL  1  (detail)  733
(-)
C--792
(-)
-Positive
Hu, 2011
* Recently Added *
Overlaps with
Naj, 2011 (GenADA)
CL  1  (detail)  798
(-)
C--776
(-)
-n.a.
Hu, 2011
* Recently Added *
Overlaps with
Naj, 2011 (ADNI)
CL  1  (detail)  300
(-)
C--196
(-)
-n.a.
Jun, 2010
Israel (ADGC-Wadi Ara) CL  8  (detail)  124
(-)
M--142
(-)
-Negative
Jun, 2010
Overlaps with
Naj, 2011
CL  9  (detail)  5935
(-)
M--7034
(-)
-n.a.
Kamboh, 2010
Overlaps with
Naj, 2011
CL  2  (detail)  1348
(66%)
M72.6 + 6.4
(-)
-1359
(61%)
74.7 + 6.5
(-)
n.a.
Lambert, 2009
Stage 1 (France) CL  2  (detail)  2025
(66%)
C68.3 + 9
(-)
73.7 + 8.9
(-)
5328
(61%)
73.8 + 5.4
(-)
Positive
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Naj, 2011
* Recently Added *
USA (ADGC-GWAS) CL  1  (detail)  8309
(61%)
M--7366
(58%)
-Positive
Naj, 2011
* Recently Added *
USA (ADGC-REP) CL  1  (detail)  3531
(60%)
M--3565
(61%)
-Positive
Reiman, 2007
Overlaps with
Naj, 2011
CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
n.a.
Seshadri, 2010
Europe (CHARGE; GWAS) CL  1  (detail)  1367
(-)
M--20866
(-)
-Negative
Seshadri, 2010
Overlaps with
Naj, 2011
CL  1  (detail)  829
(52%)
M-80 + 10
(-)
536
(63%)
80 + 7
(-)
n.a.
Seshadri, 2010
Overlaps with
Harold, 2009 (GERAD1; Stage 1)
CL  1  (detail)  810
(57%)
M-73 + 4
(-)
1202
(50%)
74 + 5
(-)
n.a.
Seshadri, 2010
Overlaps with
Lambert, 2009 (EADI1; Stage2)
CL  1  (detail)  2025
(66%)
C68.3 + 9
(-)
73.7 + 8.9
(-)
5328
(61%)
73.8 + 5.4
(-)
n.a.
Seshadri, 2010
Overlaps with
Harold, 2009 (GERAD1; Stage 3)
CL  1  (detail)  3333
(-)
M--6995
(-)
-n.a.
Seshadri, 2010
Spain (ACE) CL  1  (detail)  1140
(70%)
C-78.8 + 7.9
(-)
1209
(53%)
49.9 + 9.2
(-)
Positive
 African Descent
Jun, 2010
USA (ADGC-AA) CL  9  (detail)  462
(-)
M--449
(-)
-Negative
 Hispanic
Jun, 2010
USA (ADGC-H) CL  5  (detail)  549
(-)
M--544
(-)
-Negative
Lee, 2011
* Recently Added *
Overlaps with
Jun, 2010 (ADGC-H)
CL,PO  5  (detail)  549
(-)
C79.9 + 8
(-)
-544
(-)
78.8 + 6.4
(-)
n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Wijsman, 2011
* Recently Added *
Overlaps with
Naj, 2011
 4  (detail)  6111848
(-)
M--1991
(-)
-n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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