AlzGene - Gene overview of all published AD-association studies for CST3
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 Gene: CST3  (AD8)  Entrez Gene    View on ALSGene
 Protein: cystatin C  (cystatin 3; gamma-trace; post-gamma-globulin; neuroendocrine basic polypeptide)  ProteinLink
 Chromosome: 20   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Beyer, 2001
Spain CL,CO  1  (detail)  159
(62%)
C-71.8
(48-84)
155
(66%)
69.2
(50-84)
Positive
Beyer, 2005
Overlaps with
Beyer, 2001
CL  1  (detail)  206
(62%)
C-72.6
(48-85)
181
(60%)
69.6
(45-84)
n.a.
Cathcart, 2005
USA CL  1  (detail)  179
(70%)
C71 + 8
(-)
-141
(59%)
72 + 8
(-)
Positive
Corder, 2006
Overlaps with
Cathcart, 2005
CL  1  (detail)  ------n.a.
Crawford, 2000
USA CL,CO  1  (detail)  309
(56%)
C75.1 + 7.4
(-)
-134
(64%)
76.1 + 7.4
(-)
Positive
Dodel, 2002
Germany CL  2  (detail)  287
(59%)
C-70.4 + 9.3
(51-90)
181
(64%)
68.1 + 10.6
(50-93)
Negative
Feulner, 2009
Germany CL  4  (detail)  491
(57%)
C-72.2
(-)
479
(46%)
39.5
(-)
Negative
Finckh, 2000
Germany CL  3  (detail)  110
(72%)
C-73.1 + 8.9
(-)
150
(44%)
65.2 + 14.6
(-)
Positive
Finckh, 2000
USA & Europe CL,PO  3  (detail)  407
(70%)
C-75 + 9.5
(-)
240
(58%)
75.1 + 6.3
(-)
Positive
Giedraitis, 2009
Sweden (ULSAM) CL  1  (detail)  86
(0%)
C80.2
(72-85)
-404
(0%)
81.8
(80-84)
Negative
Goddard, 2004
USA (NIMH) CL  1  (detail)  89
(79%)
M79.7 + 5.7
(65-93)
91.5 + 4.6
(82-105)
24
(58%)
86.2 + 2.1
(84-93)
Negative
Goddard, 2004
USA (OBAS) CO  1  (detail)  41
(61%)
C91.1 + 3.3
(86-100)
94.2 + 3.3
(87-103)
88
(65%)
89.5 + 3.2
(86-99)
Negative
Helisalmi, 2009
Finland CL  2  (detail)  568
(69%)
C71 + 7
(-)
-688
(60%)
69 + 6
(-)
Negative
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Monastero, 2005
Italy    1  (detail)  192
(64%)
C-73.3 + 7.8
(51-89)
192
(64%)
72.6 + 7.9
(52-89)
Negative
Nacmias, 2005
Italy CL  1  (detail)  243
(64%)
C69.7 + 7.8
(-)
-186
(67%)
72.9 + 24
(26-108)
Negative
Randall, 2009
Overlaps with
Cathcart, 2005
CL  1  (detail)  181
(71%)
C--119
(52%)
-n.a.
Reiman, 2007
USA, Netherlands CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Roks, 2001
Netherlands PO  1  (detail)  101
(77%)
C57 + 5
(-)
-117
(55%)
61 + 3.3
(-)
Negative
 Asian
Chuo, 2007
Taiwan CL  1  (detail)  175
(-)
C-76.9 + 7.2
(60-96)
461
(-)
77.3 + 5.5
(60-91)
Positive
Lin, 2003
Overlaps with
Chuo, 2007
   1  (detail)  124
(-)
U--115
(-)
-n.a.
Maruyama, 2001
Japan CL,PO  2  (detail)  179
(71%)
C71 + 10.3
(-)
-228
(56%)
70.2 + 9.6
(-)
Negative
Wang, 2008
China CL  1  (detail)  281
(49%)
C-76.7 + 6.6
(65-97)
376
(46%)
71.8 + 5.7
(65-87)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Other/Mixed
Schjeide, 2009
USA (CAG)  1  (detail)  217222
(59%)
M69.2 + 9
(50-89)
-267
(63%)
72.9 + 8.8
(49-92)
Negative
Schjeide, 2009
USA (NCRAD)  1  (detail)  340741
(74%)
M71.3 + 7.6
(50-98)
-300
(55%)
71 + 8.4
(39-93)
Trend
Schjeide, 2009
USA (NIA)  1  (detail)  351803
(64%)
M74.1 + 7.1
(52-98)
-290
(59%)
73.3 + 9.5
(36-94)
Negative
Schjeide, 2009
USA (NIMH)  1  (detail)  436995
(74%)
M72.4 + 7.7
(50-97)
-411
(58%)
70 + 10.7
(31-93)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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