AlzGene - Gene overview of all published AD-association studies for IL1B
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 Gene: IL1B  (IL-1B; IL1-Beta; IL1F2; Catabolin)  Entrez Gene    View on MSGene   View on PDGene   View on SZGene
 Protein: interleukin 1, beta   ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Bosco, 2004
 Italy    1  (detail)  152
(54%)		C-74.8
(47-99)		136
(55%)		69.3
(55-99)		Positive
Deniz-Naranjo, 2008
 Spain CL  1  (detail)  282
(69%)		C--312
(38%)		-Positive
Ehl, 2003
 Germany CL  1  (detail)  111
(66%)		C-74.1 + 9.5
(-)		186
(51%)		65.6 + 8.8
(-)		Negative
Giedraitis, 2009
 Sweden (ULSAM) CL  1  (detail)  86
(0%)		C80.2
(72-85)		-404
(0%)		81.8
(80-84)		Negative
Green, 2002
 UK CL  1  (detail)  294
(64%)		M-63.9 + 6.8
(-)		503
(49%)		62.6 + 5.3
(-)		Negative
Grimaldi, 2000
 Italy CL  1  (detail)  318
(63%)		C-66.9 + 9.2
(35-90)		335
(40%)		69.3 + 10.4
(53-98)		Positive
Hedley, 2002
 Australia CL  2  (detail)  222
(-)		U--352
(-)		76.6 + 10.2
(-)		Positive
Klimkowicz, 2009
 Poland CL  1  (detail)  332
(64%)		C-75.8 + 5.5
(-)		220
(60%)		75.2 + 7.3
(-)		Negative
Licastro, 2000
 Overlaps with
Grimaldi, 2000		 CL  1  (detail)  281
(61%)		C-74.4 + 1
(-)		201
(32%)		68.9 + 1
(-)		n.a.
Licastro, 2006
 Overlaps with
Grimaldi, 2000		 CL  1  (detail)  260
(-)		C--190
(-)		-n.a.
Mattila, 2002
 Finland CL  1  (detail)  92
(68%)		M-80.5 + 5.5
(-)		73
(47%)		75.3 + 7.5
(-)		Negative
McCulley, 2004
 UK CL  1  (detail)  133
(42%)		C73 + 4.2
(-)		78.5 + 6.6
(-)		156
(-)		-Negative
Minster, 2000
 USA CL  1  (detail)  335
(65%)		M70.8 + 6.2
(-)		76.9 + 6.4
(-)		205
(70%)		74.1 + 5.9
(-)		Negative
Nicoll, 2000
 USA & Europe CL  1  (detail)  233
(-)		N-81.5 + 7.8
(-)		169
(-)		74.4 + 9.6
(-)		Positive
Ravaglia, 2005
 Italy CO  1  (detail)  105
(73%)		C-80.6 + 7.8
(-)		644
(52%)		73 + 5.9
(-)		Negative
Rosenmann, 2004
 USA CL  1  (detail)  108
(55%)		C72.7
(50-88)		-104
(61%)		77.4
(62-91)		Negative
Sciacca, 2003
 Italy CL  1  (detail)  353
(62%)		C-72.8 + 8.7
(-)		482
(50%)		55 + 20.2
(-)		Positive
Seripa, 2005
 Italy CL  1  (detail)  237
(68%)		C67
(49-92)		75 + 7.9
(54-90)		147
(64%)		72.1 + 9.1
(58-94)		Positive
Seripa, 2005
 USA CL  1  (detail)  124
(54%)		C73
(50-88)		80.9 + 7.6
(64-98)		97
(53%)		84 + 8.6
(65-105)		Negative
Wehr, 2006
 Poland CL  2  (detail)  100
(66%)		C-71.8 + 7.9
(52-91)		144
(53%)		70.5 + 8.8
(47-93)		Positive
 Asian
Li, 2004
 China CL,PO  1  (detail)  145
(57%)		C69.4 + 9.4
(45-90)		-181
(45%)		69.9 + 7.7
(48-90)		Negative
Ma, 2003
 China CL  3  (detail)  90
(76%)		C-77
(61-90)		100
(76%)		73
(61-85)		Negative
Nishimura, 2004
 Japan CL  1  (detail)  172
(60%)		C-77.4 + 9.7
(55-96)		163
(61%)		75.5 + 9.9
(-)		Negative
Wang, 2005
 Taiwan    2  (detail)  46
(-)		C73.1 + 5.8
(-)		-103
(-)		67.4 + 4.8
(-)		Positive
Wang, 2007
 Taiwan CL  1  (detail)  219
(62%)		C-75.6 + 8.3
(-)		209
(46%)		71.2 + 6.7
(-)		Negative
Yucesoy, 2005
 USA CO  2  (detail)  179
(0%)		C--517
(0%)		80 + 5.3
(-)		Positive
 Other/Mixed
Oliveira, 2008
 Brazil CL  1  (detail)  195
(-)		C-68.7 + 8
(-)		188
(-)		72.3 + 9.7
(-)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Other/Mixed
Bertram, 2000
 USA  1  (detail)  220460
(-)		M--367
(-)		-Negative
Schjeide, 2009
 USA (CAG)  1  (detail)  217222
(59%)		M69.2 + 9
(50-89)		-267
(63%)		72.9 + 8.8
(49-92)		Negative
Schjeide, 2009
 USA (NCRAD)  1  (detail)  340741
(74%)		M71.3 + 7.6
(50-98)		-300
(55%)		71 + 8.4
(39-93)		Negative
Schjeide, 2009
 USA (NIA)  1  (detail)  351803
(64%)		M74.1 + 7.1
(52-98)		-290
(59%)		73.3 + 9.5
(36-94)		Negative
Schjeide, 2009
 USA (NIMH)  1  (detail)  436995
(74%)		M72.4 + 7.7
(50-97)		-411
(58%)		70 + 10.7
(31-93)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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