AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs754203
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 Polymorphism: rs754203 (2i)
 Gene: CYP46A1  (CP46; CYP46)  Entrez Gene
 Protein: cytochrome P450, family 46, subfamily A, polypeptide 1   ProteinLink
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   C-Allele
(frequency)		 T-Allele
(frequency)		 C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian 17 AD
CTR		 0.30
0.29		 0.70
0.71		 368 (0.090)
295 (0.077)		 1715 (0.420)
1600 (0.418)		 2003 (0.490)
1936 (0.505)
 African Descent 1 AD
CTR		 0.18
0.17		 0.82
0.83		 1 (0.019)
2 (0.033)		 17 (0.315)
17 (0.279)		 36 (0.667)
42 (0.689)
 Asian 4 AD
CTR		 0.28
0.29		 0.72
0.71		 50 (0.082)
43 (0.076)		 248 (0.405)
240 (0.423)		 314 (0.513)
285 (0.502)
 Other/Mixed 1 AD
CTR		 0.30
0.29		 0.70
0.71		 19 (0.107)
5 (0.048)		 69 (0.388)
51 (0.486)		 90 (0.506)
49 (0.467)
Total 23 AD
CTR		 0.30
0.29		 0.70
0.72		 438 (0.089)
345 (0.076)		 2049 (0.416)
1908 (0.418)		 2443 (0.496)
2312 (0.506)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs754203 (2i)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

CYP46A1_intron2 (II)
CYP46A1_IVS9+293T/A
rs2146238
rs2273839
rs2273840
rs2295911
rs34779504
rs36018216
rs3742375
rs3742376
rs3742377
rs3752958
rs3830998
rs7157609
rs8022722
rs911913
rs943880
rs943881

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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.