AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs1800682
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 Polymorphism: rs1800682 (-670)
 Gene: FAS  (APT1; CD95; FAS1; APO-1; FASTM; ALPS1A;; TNFRSF6; Apo-1 Fas)  Entrez Gene    View on MSGene
 Protein: Fas (TNF receptor superfamily, member 6)  (TNF receptor superfamily, member 6)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  G-Allele
(frequency)
A-Allele
(frequency)
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian 8 AD
CTR
0.44
0.44
0.56
0.56
266 (0.207)
226 (0.189)
607 (0.472)
606 (0.506)
412 (0.321)
366 (0.306)
 Asian 1 AD
CTR
0.38
0.38
0.62
0.62
80 (0.157)
96 (0.163)
224 (0.440)
251 (0.427)
205 (0.403)
241 (0.410)
Total 9 AD
CTR
0.42
0.42
0.58
0.58
346 (0.193)
322 (0.180)
831 (0.463)
857 (0.480)
617 (0.344)
607 (0.340)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1800682 (-670)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs1051070
rs1159120
rs1324551
rs1468063
rs1571011
rs1571013
rs1571020
rs1926188
rs1926195
rs1926196
rs2031612
rs2234767 (-1377)
rs2234768
rs2234978 (exon 7)
rs2234979
rs2296600
rs4064
rs874145
rs913943
rs978522
rs982764
rs983751

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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.