AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs11568822
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 Polymorphism: rs11568822 (ins/del-HpaI)
 Gene: APOC1   Entrez Gene    View on MSGene
 Protein: apolipoprotein C-I   ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  ins-Allele
(frequency)
del-Allele
(frequency)
ins/ins
(frequency)
ins/del
(frequency)
del/del
(frequency)
 Caucasian 6 AD
CTR
0.36
0.20
0.64
0.81
76 (0.126)
37 (0.050)
285 (0.471)
217 (0.291)
244 (0.403)
491 (0.659)
 African Descent 1 AD
CTR
0.27
0.23
0.73
0.77
14 (0.108)
15 (0.065)
42 (0.323)
77 (0.335)
74 (0.569)
138 (0.600)
 Asian 3 AD
CTR
0.27
0.16
0.73
0.84
30 (0.063)
8 (0.019)
193 (0.405)
124 (0.291)
253 (0.532)
294 (0.690)
 Hispanic 1 AD
CTR
0.22
0.14
0.78
0.86
14 (0.073)
12 (0.036)
56 (0.290)
70 (0.207)
123 (0.637)
256 (0.757)
 Other/Mixed 3 AD
CTR
0.43
0.26
0.57
0.74
47 (0.155)
22 (0.051)
167 (0.549)
184 (0.425)
90 (0.296)
227 (0.524)
Total 14 AD
CTR
0.32
0.20
0.68
0.80
181 (0.106)
94 (0.043)
743 (0.435)
672 (0.309)
784 (0.459)
1406 (0.647)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs11568822 (ins/del-HpaI)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs3826688
rs4420638
rs445925
rs4803770
rs483082
rs584007
rs7256200
rs7259004

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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.