AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs1799986
Back Search Methods Disclaimer Credits
 Polymorphism: rs1799986 (exon 3)
 Gene: LRP1  (APR; LRP; A2MR; CD91; APOER)  Entrez Gene    View on MSGene   View on PDGene
 Protein: low density lipoprotein-related protein 1  (alpha-2-macroglobulin receptor)  ProteinLink
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 C-Allele
(frequency)		 T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian 22 AD
CTR		 0.14
0.15		 0.86
0.85		 134 (0.022)
143 (0.024)		 1404 (0.232)
1483 (0.248)		 4505 (0.745)
4364 (0.729)
 Asian 6 AD
CTR		 0.07
0.09		 0.93
0.91		 11 (0.010)
16 (0.015)		 122 (0.113)
162 (0.153)		 942 (0.876)
878 (0.831)
 Hispanic 1 AD
CTR		 0.10
0.10		 0.90
0.90		 0 (0.000)
1 (0.010)		 22 (0.208)
18 (0.186)		 84 (0.792)
78 (0.804)
 Other/Mixed 1 AD
CTR		 0.06
0.03		 0.94
0.97		 0 (0.000)
0 (0.000)		 14 (0.126)
4 (0.051)		 97 (0.874)
74 (0.949)
Total 30 AD
CTR		 0.13
0.14		 0.87
0.86		 145 (0.020)
160 (0.022)		 1562 (0.213)
1667 (0.231)		 5628 (0.767)
5394 (0.747)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1799986 (exon 3)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

LRP_5'VNTR
rs11172124
rs1800127 (A216V)
rs1800154
rs1800164
rs1800165
rs1800174
rs1800181
rs2075699
rs2228186
rs2306692
rs7956957
rs9669595

AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.