AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs7910977
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 Polymorphism: rs7910977
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 C-Allele
(frequency)		 T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian 4 AD
CTR		 0.11
0.14		 0.89
0.87		 43 (0.019)
37 (0.015)		 420 (0.184)
572 (0.239)		 1817 (0.797)
1787 (0.746)
Total 4 AD
CTR		 0.11
0.14		 0.89
0.87		 43 (0.019)
37 (0.015)		 420 (0.184)
572 (0.239)		 1817 (0.797)
1787 (0.746)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs7910977

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

hCV11194331
hCV11194366
hCV115183
hCV1819830
hCV22272896
hCV22273765
hCV27434720
hCV27434725
IDE_SNP309 (exon 13)
IDE_SNP310 (intron 12)
IDE_variantID-2 (2bp-indel)
rs10786044
rs10882066
rs11187007
rs11187025
rs11187032
rs11187033
rs11187040
rs11187060
rs11187061
rs11187062
rs11187064
rs11187074
rs12264682
rs12416180
rs12783634
rs17107721
rs17107734
rs17445028 (hCV1819799)
rs17445328
rs17875327
rs1855915
rs1855916
rs1999763
rs2249960
rs2250090 (IDE_11)
rs2275218 (IDE_10)
rs2421940
rs2421942 (IDE_15)
rs2421943 (IDE_17)
rs2901587
rs3737225
rs3781239
rs4646955
rs5786996 (1bp-indel)
rs5786997 (2bp-indel)
rs6583817
rs7076966
rs7078413
rs7084090
rs7086285
rs7099761
rs7895832
rs7908111
rs7918084
rs967878
ss28525229
ss28525230
ss28525231

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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.