AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs2274185
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 Polymorphism: rs2274185 (18 intron 6)
 Gene: NCSTN  (APH2; KIAA0253)  Entrez Gene    View on SZGene
 Protein: nicastrin   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   G-Allele
(frequency)		 C-Allele
(frequency)		 G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian 5 AD
CTR		 0.05
0.05		 0.95
0.95		 9 (0.005)
3 (0.002)		 180 (0.093)
179 (0.104)		 1756 (0.903)
1535 (0.894)
Total 5 AD
CTR		 0.05
0.05		 0.95
0.95		 9 (0.005)
3 (0.002)		 180 (0.093)
179 (0.104)		 1756 (0.903)
1535 (0.894)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs2274185 (18 intron 6)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

13 intron 9
3'UTR 2514
E79E
N417Y
rs10494342
rs10752637 (T796G)
rs1324738 (-436C/T)
rs17370539 (-119 intron 16)
rs2038781
rs2147471 (C1216A)
rs4656256
rs6427515
rs6664627 (D249D)
rs6668576

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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.