AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs5853711
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 Polymorphism: rs5853711 (-1784 (gt)p)
 Gene: MME  (NEP; CD10; CALLA)  Entrez Gene
 Protein: neprilysin  (membrane metallo-endopeptidase; neutral endopeptidase; enkephalinase)  ProteinLink
 Chromosome: 3   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   22-Allele
(frequency)		 non22-Allele
(frequency)		 22/22
(frequency)		 22/non22
(frequency)		 non22/non22
(frequency)
 Caucasian 2 AD
CTR		 0.05
0.06		 0.95
0.94		 2 (0.003)
2 (0.005)		 56 (0.092)
43 (0.106)		 552 (0.905)
362 (0.889)
 Asian 3 AD
CTR		 0.02
0.01		 0.98
0.99		 0 (0.000)
0 (0.000)		 23 (0.045)
11 (0.024)		 493 (0.955)
447 (0.976)
Total 5 AD
CTR		 0.04
0.03		 0.96
0.97		 2 (0.002)
2 (0.002)		 79 (0.070)
54 (0.062)		 1045 (0.928)
809 (0.935)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs5853711 (-1784 (gt)p)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

c401
IVS10-5C
IVS15+144
IVS17-294
IVS22+36
IVS3+106
MME_204
rs10513467
rs10622201 (Intron 22 (TG)p)
rs11925306
rs13077421
rs13081581
rs1385477
rs16846960
rs1816558
rs1836915
rs2196521
rs34745881 (Intron 3 (CA)p)
rs35994024 (-2419 (ac)p)
rs3736187
rs3773882
rs3773885
rs3773906
rs3773907
rs4432598
rs6776185
rs6801319
rs7623854
rs9834487
rs9853221
rs9881879

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3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.