AlzGene

AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs405509

Polymorphism:

rs405509 (Th1/E47cs)

Gene:

APOE (AD2; MGC1571)

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Protein:

apolipoprotein E (Alzheimer disease 2)

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		G-Allele (frequency)	T-Allele (frequency)	G/G (frequency)	G/T (frequency)	T/T (frequency)
Caucasian	24	AD CTR	0.44 0.52	0.56 0.48	2347 (0.189) 4601 (0.276)	6178 (0.498) 8245 (0.495)	3880 (0.313) 3822 (0.229)
African Descent	1	AD CTR	0.76 0.72	0.24 0.28	83 (0.585) 132 (0.526)	50 (0.352) 99 (0.394)	9 (0.063) 20 (0.080)
Asian	1	AD CTR	0.22 0.29	0.78 0.71	8 (0.033) 25 (0.077)	88 (0.365) 138 (0.425)	145 (0.602) 162 (0.498)
Hispanic	1	AD CTR	0.59 0.60	0.41 0.40	78 (0.339) 130 (0.362)	114 (0.496) 168 (0.468)	38 (0.165) 61 (0.170)
Other/Mixed	1	AD CTR	0.34 0.43	0.66 0.57	3 (0.038) 12 (0.179)	48 (0.608) 34 (0.507)	28 (0.354) 21 (0.313)
Total	28	AD CTR	0.44 0.52	0.56 0.48	2519 (0.192) 4900 (0.277)	6478 (0.495) 8684 (0.491)	4100 (0.313) 4086 (0.231)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs405509 (Th1/E47cs)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

APOE_GWAS
APOE_ME.1
rs1081105
rs1081106
rs429358
rs7412
rs769448
rs769449
rs769450

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.

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SZGene

An up-to-date collection of all published genetic association studies.