AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Shibata, 2005
 Gene: CH25H  (C25H)  Entrez Gene
 Protein: cholesterol 25-hydroxylase   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   n.g.-Allele n.g.-Allele n.g./n.g.
(frequency)		 n.g./n.g.
(frequency)		 n.g./n.g.
(frequency)
 Caucasian
rs1892336 USA, Canada AD
CTR		 0.20
0.20		 0.80
0.80		 9 (0.041)
8 (0.041)		 70 (0.320)
62 (0.318)		 140 (0.639)
125 (0.641)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2841031 USA, Canada AD
CTR		 0.28
0.33		 0.72
0.67		 17 (0.078)
21 (0.108)		 88 (0.404)
86 (0.441)		 113 (0.518)
88 (0.451)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs17382301 (N219N) USA, Canada AD
CTR		 0.09
0.12		 0.91
0.88		 2 (0.009)
3 (0.015)		 36 (0.164)
41 (0.210)		 181 (0.826)
151 (0.774)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4078488 (A168A) USA, Canada AD
CTR		 0.16
0.13		 0.84
0.87		 6 (0.027)
3 (0.015)		 59 (0.269)
44 (0.226)		 154 (0.703)
148 (0.759)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   n.g.-Allele n.g.-Allele n.g./n.g.
(frequency)		 n.g./n.g.
(frequency)		 n.g./n.g.
(frequency)
 Caucasian
rs10887932 USA, Canada AD
CTR		 0.16
0.14		 0.84
0.86		 6 (0.027)
4 (0.021)		 59 (0.269)
47 (0.241)		 154 (0.703)
144 (0.738)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs4417181 USA, Canada AD
CTR		 0.16
0.14		 0.84
0.86		 6 (0.027)
4 (0.021)		 59 (0.269)
47 (0.241)		 154 (0.703)
144 (0.738)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs13500 USA, Canada AD
CTR		 0.16
0.13		 0.84
0.87		 6 (0.027)
3 (0.015)		 59 (0.269)
44 (0.226)		 154 (0.703)
148 (0.759)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs17382301 (N219N) Mixed AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs4078488 (A168A) Mixed AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.