AlzGene - Polymorphism Details
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 Study: Shibata, 2006
 Gene: PLAT  (TPA; T-PA; DKFZp686I03148)  Entrez Gene    View on MSGene
 Protein: plasminogen activator, tissue   ProteinLink
 Chromosome: 8   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 11 February 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   D-Allele I-Allele D/D
(frequency)
D/I
(frequency)
I/I
(frequency)
 Caucasian
rs4646972 (Alu ins/del) Europe (mixed) AD
CTR
0.61
0.40
0.39
0.60
77 (0.405)
29 (0.149)
77 (0.405)
99 (0.510)
36 (0.189)
66 (0.340)
rs4646972 (Alu ins/del) Canada AD
CTR
0.51
0.49
0.49
0.51
59 (0.311)
76 (0.310)
74 (0.389)
88 (0.359)
57 (0.300)
81 (0.331)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs2020923 Europe (mixed) AD
CTR
0.11
0.07
0.89
0.93
2 (0.010)
0 (0.000)
38 (0.198)
27 (0.138)
152 (0.792)
168 (0.862)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1058720 Canada AD
CTR
0.33
0.38
0.67
0.62
15 (0.079)
37 (0.151)
95 (0.503)
110 (0.449)
79 (0.418)
98 (0.400)
rs1058720 Europe (mixed) AD
CTR
0.53
0.41
0.47
0.59
54 (0.281)
21 (0.108)
96 (0.500)
119 (0.610)
42 (0.219)
55 (0.282)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2070711 Europe (mixed) AD
CTR
0.10
0.08
0.90
0.92
2 (0.010)
0 (0.000)
36 (0.188)
31 (0.159)
154 (0.802)
164 (0.841)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   D-Allele I-Allele D/D
(frequency)
D/I
(frequency)
I/I
(frequency)
 Caucasian
rs4646972 (Alu ins/del) Europe (mixed) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4646972 (Alu ins/del) USA (Carribean) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1058720 USA (Carribean) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs1058720 Europe (mixed) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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