AlzGene - Polymorphism Details
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 Study: Kawamata, 2002
 Gene: CHRNA3  (MGC104879)  Entrez Gene    View on PDGene   View on SZGene
 Protein: cholinergic receptor, nicotinic, alpha polypeptide 3   ProteinLink
 Chromosome: 15   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 12 August 2005
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   8-Allele 7-Allele 6-Allele 8/8
(frequency)		 8/7
(frequency)		 7/7
(frequency)		 8/6
(frequency)		 7/6
(frequency)		 6/6
(frequency)
 Asian
p(CTG) exon 1 Japan AD
CTR		 0.01
0.05		 0.22
0.23		 0.78
0.72		 0 (0.000)
0 (0.000)		 0 (0.000)
4 (0.063)		 3 (0.052)
4 (0.063)		 1 (0.017)
3 (0.047)		 19 (0.328)
17 (0.266)		 35 (0.603)
36 (0.563)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Asian
rs804868 (A345G) Japan AD
CTR		 0.28
0.31		 0.72
0.69		 5 (0.086)
5 (0.096)		 23 (0.397)
22 (0.423)		 30 (0.517)
25 (0.481)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T5-Allele T4-Allele T5/T5
(frequency)		 T5/T4
(frequency)		 T4/T4
(frequency)
 Asian
409 -36 polyT Japan AD
CTR		 0.03
0.03		 0.97
0.97		 0 (0.000)
0 (0.000)		 3 (0.052)
3 (0.058)		 55 (0.948)
49 (0.942)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Asian
rs3743074 (454 -5 C>T) Japan AD
CTR		 0.47
0.63		 0.53
0.37		 13 (0.224)
21 (0.404)		 29 (0.500)
24 (0.462)		 16 (0.276)
7 (0.135)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Asian
A477G Japan AD
CTR		 0.47
0.63		 0.53
0.37		 13 (0.224)
21 (0.404)		 29 (0.500)
24 (0.462)		 16 (0.276)
7 (0.135)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Asian
563+8 G>C Japan AD
CTR		 0.04
0.07		 0.96
0.93		 0 (0.000)
0 (0.000)		 5 (0.086)
7 (0.135)		 53 (0.914)
45 (0.865)
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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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