AlzGene

AlzGene - Polymorphism Details

Study:

Forsell, 2008

Gene:

COL25A1 (CLAC; CLACP)

Protein:

collagen, type XXV, alpha 1 (collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component)

Chromosome:

4 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 5 June 2008

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs17531474	Sweden (I)	AD CTR	0.15 0.11	0.85 0.89	18 (0.022) 4 (0.011)	212 (0.261) 74 (0.206)	583 (0.717) 282 (0.783)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	A-Allele	T/T (frequency)	T/A (frequency)	A/A (frequency)
Caucasian
rs12511927	Sweden (I)	AD CTR	0.21 0.16	0.79 0.84	35 (0.043) 9 (0.025)	277 (0.339) 101 (0.278)	504 (0.618) 253 (0.697)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1364842	Sweden (I)	AD CTR	0.24 0.19	0.76 0.81	49 (0.060) 12 (0.033)	296 (0.364) 114 (0.317)	469 (0.576) 234 (0.650)
rs1364842	Sweden (II)	AD CTR	0.25 0.23	0.75 0.77	14 (0.055) 43 (0.066)	102 (0.398) 216 (0.331)	140 (0.547) 394 (0.603)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs17596705	Sweden (II)	AD CTR	0.26 0.25	0.74 0.75	15 (0.061) 49 (0.076)	99 (0.404) 219 (0.341)	131 (0.535) 375 (0.583)
rs17596705	Sweden (I)	AD CTR	0.25 0.20	0.75 0.80	50 (0.063) 9 (0.025)	292 (0.368) 125 (0.351)	452 (0.569) 222 (0.624)

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

Proud supporter of the AlzGene database.

The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.

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An up-to-date collection of all published genetic association studies.