AlzGene - Polymorphism Details
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 Study: Koelsch, 2008
 Gene: RXRA  (NR2B1)  Entrez Gene
 Protein: retinoid X receptor, alpha   ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 26 January 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2266677 Germany AD
CTR		 0.22
0.21		 0.78
0.79		 19 (0.047)
14 (0.040)		 140 (0.346)
116 (0.334)		 246 (0.607)
217 (0.625)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1805352 Germany AD
CTR		 0.33
0.31		 0.67
0.69		 40 (0.099)
44 (0.127)		 186 (0.459)
128 (0.369)		 179 (0.442)
175 (0.504)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3118570 Germany AD
CTR		 0.19
0.18		 0.81
0.82		 8 (0.020)
16 (0.046)		 136 (0.336)
90 (0.259)		 261 (0.644)
241 (0.695)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1536475 Germany AD
CTR		 0.20
0.17		 0.80
0.83		 18 (0.044)
19 (0.055)		 130 (0.321)
82 (0.236)		 257 (0.635)
246 (0.709)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs3132293 Germany AD
CTR		 0.28
0.22		 0.72
0.78		 25 (0.062)
24 (0.069)		 177 (0.437)
107 (0.308)		 203 (0.501)
216 (0.622)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
RXRA_IVS8 Germany AD
CTR		 0.02
0.03		 0.98
0.97		 5 (0.012)
9 (0.026)		 8 (0.020)
5 (0.014)		 392 (0.968)
333 (0.960)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1805343 Germany AD
CTR		 0.38
0.34		 0.62
0.66		 64 (0.158)
52 (0.150)		 179 (0.442)
129 (0.372)		 162 (0.400)
166 (0.478)
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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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