AlzGene - Polymorphism Details
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 Study: Lambert, 2009
 Gene: PCDH11X  (PCDHX; PCDH11; PCDH-X; PCDH11X; PCDHY)  Entrez Gene    View on SZGene
 Protein: protocadherin 11 X-linked   ProteinLink
 Chromosome: X   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 17

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs5984894 France (Stage 1 - Men) AD
CTR
0.46
0.47
0.54
0.53
315 (0.462)
932 (0.475)
0 (0.000)
0 (0.000)
367 (0.538)
1031 (0.525)
rs5984894 France (Stage 1 - Women) AD
CTR
0.48
0.49
0.52
0.51
311 (0.237)
780 (0.240)
649 (0.494)
1605 (0.494)
355 (0.270)
864 (0.266)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs5941047 France (Stage 1 - Men) AD
CTR
0.36
0.37
0.64
0.63
246 (0.358)
754 (0.367)
0 (0.000)
0 (0.000)
442 (0.642)
1299 (0.633)
rs5941047 France (Stage 1 - Women) AD
CTR
0.39
0.39
0.61
0.61
206 (0.156)
507 (0.155)
604 (0.458)
1512 (0.464)
509 (0.386)
1243 (0.381)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs2574054 France (Stage 1 - Women) AD
CTR
0.46
0.45
0.54
0.55
292 (0.222)
658 (0.202)
640 (0.486)
1623 (0.499)
386 (0.293)
971 (0.299)
rs2574054 France (Stage 1 - Men) AD
CTR
0.48
0.44
0.52
0.56
330 (0.480)
904 (0.441)
0 (0.000)
0 (0.000)
357 (0.520)
1144 (0.559)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs11091840 France (Stage 1 - Men) AD
CTR
0.48
0.46
0.52
0.54
325 (0.477)
932 (0.459)
0 (0.000)
0 (0.000)
356 (0.523)
1097 (0.541)
rs11091840 France (Stage 1 - Women) AD
CTR
0.46
0.47
0.54
0.53
301 (0.229)
751 (0.231)
615 (0.467)
1588 (0.488)
401 (0.304)
917 (0.282)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs5985006 France (Stage 1 - Women) AD
CTR
0.46
0.48
0.54
0.52
291 (0.221)
770 (0.237)
641 (0.487)
1591 (0.489)
384 (0.292)
891 (0.274)
rs5985006 France (Stage 1 - Men) AD
CTR
0.49
0.40
0.51
0.60
325 (0.485)
747 (0.395)
0 (0.000)
0 (0.000)
345 (0.515)
1143 (0.605)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs810845 France (Stage 1 - Men) AD
CTR
0.47
0.41
0.53
0.59
322 (0.467)
846 (0.414)
0 (0.000)
0 (0.000)
368 (0.533)
1197 (0.586)
rs810845 France (Stage 1 - Women) AD
CTR
0.44
0.44
0.56
0.56
268 (0.203)
624 (0.191)
633 (0.481)
1641 (0.503)
416 (0.316)
996 (0.305)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs12009352 France (Stage 1 - Men) AD
CTR
0.41
0.37
0.59
0.63
283 (0.412)
766 (0.372)
0 (0.000)
0 (0.000)
404 (0.588)
1292 (0.628)
rs12009352 France (Stage 1 - Women) AD
CTR
0.40
0.41
0.60
0.59
216 (0.164)
557 (0.171)
620 (0.470)
1554 (0.477)
482 (0.366)
1150 (0.353)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4568761 France (Stage 1 - Men) AD
CTR
0.38
0.39
0.62
0.61
264 (0.384)
804 (0.391)
0 (0.000)
0 (0.000)
424 (0.616)
1251 (0.609)
rs4568761 France (Stage 1 - Women) AD
CTR
0.40
0.41
0.60
0.59
228 (0.173)
564 (0.173)
612 (0.464)
1548 (0.475)
479 (0.363)
1150 (0.353)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs6418096 France (Stage 1 - Men) AD
CTR
0.31
0.31
0.69
0.69
215 (0.311)
644 (0.313)
0 (0.000)
0 (0.000)
476 (0.689)
1411 (0.687)
rs6418096 France (Stage 1 - Women) AD
CTR
0.30
0.31
0.70
0.69
129 (0.098)
289 (0.089)
540 (0.410)
1422 (0.437)
647 (0.492)
1540 (0.474)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs12858374 France (Stage 1 - Women) AD
CTR
0.25
0.25
0.75
0.75
93 (0.071)
208 (0.064)
476 (0.361)
1228 (0.377)
748 (0.568)
1823 (0.559)
rs12858374 France (Stage 1 - Men) AD
CTR
0.25
0.23
0.75
0.77
171 (0.251)
465 (0.232)
0 (0.000)
0 (0.000)
509 (0.749)
1537 (0.768)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs438108 France (Stage 1 - Men) AD
CTR
0.21
0.19
0.79
0.81
143 (0.207)
384 (0.187)
0 (0.000)
0 (0.000)
547 (0.793)
1673 (0.813)
rs438108 France (Stage 1 - Women) AD
CTR
0.21
0.20
0.79
0.80
52 (0.040)
119 (0.036)
444 (0.337)
1037 (0.318)
820 (0.623)
2107 (0.646)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs453810 France (Stage 1 - Women) AD
CTR
0.23
0.22
0.77
0.78
70 (0.053)
152 (0.047)
457 (0.346)
1155 (0.354)
792 (0.600)
1954 (0.599)
rs453810 France (Stage 1 - Men) AD
CTR
0.20
0.21
0.80
0.79
142 (0.205)
436 (0.212)
0 (0.000)
0 (0.000)
551 (0.795)
1621 (0.788)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs370928 France (Stage 1 - Men) AD
CTR
0.18
0.18
0.82
0.82
126 (0.181)
376 (0.183)
0 (0.000)
0 (0.000)
569 (0.819)
1675 (0.817)
rs370928 France (Stage 1 - Women) AD
CTR
0.20
0.19
0.80
0.81
56 (0.042)
117 (0.036)
408 (0.309)
1035 (0.317)
855 (0.648)
2109 (0.647)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs117393 France (Stage 1 - Women) AD
CTR
0.20
0.19
0.80
0.81
56 (0.042)
117 (0.036)
408 (0.309)
1037 (0.318)
855 (0.648)
2109 (0.646)
rs117393 France (Stage 1 - Men) AD
CTR
0.18
0.18
0.82
0.82
124 (0.179)
373 (0.182)
0 (0.000)
0 (0.000)
569 (0.821)
1675 (0.818)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs5942313 France (Stage 1 - Men) AD
CTR
0.18
0.19
0.82
0.82
119 (0.178)
370 (0.185)
0 (0.000)
0 (0.000)
550 (0.822)
1630 (0.815)
rs5942313 France (Stage 1 - Women) AD
CTR
0.21
0.22
0.79
0.78
70 (0.053)
169 (0.052)
422 (0.320)
1091 (0.335)
825 (0.626)
1999 (0.613)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs5942003 France (Stage 1 - Men) AD
CTR
0.15
0.15
0.85
0.85
106 (0.153)
317 (0.155)
0 (0.000)
0 (0.000)
585 (0.847)
1733 (0.845)
rs5942003 France (Stage 1 - Women) AD
CTR
0.16
0.16
0.84
0.84
33 (0.025)
85 (0.026)
360 (0.274)
867 (0.266)
923 (0.701)
2310 (0.708)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Caucasian
rs5984802 France (Stage 1 - Women) AD
CTR
0.08
0.09
0.92
0.91
11 (0.008)
33 (0.010)
200 (0.152)
532 (0.165)
1101 (0.839)
2665 (0.825)
rs5984802 France (Stage 1 - Men) AD
CTR
0.09
0.08
0.91
0.92
63 (0.092)
153 (0.080)
0 (0.000)
0 (0.000)
621 (0.908)
1764 (0.920)
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Genes: 695
Polymorphisms: 2973
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