AlzGene - Polymorphism Details
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 Study: Szymanski, 2008
 Gene: NGB   Entrez Gene
 Protein: neuroglobin   ProteinLink
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 25 May 2009
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs10133981 USA (NIMH, NCRAD) AD
CTR		 0.04
0.03		 0.96
0.97		 1 (0.003)
1 (0.003)		 28 (0.080)
14 (0.048)		 322 (0.917)
274 (0.948)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2216089 USA (NIMH, NCRAD) AD
CTR		 0.40
0.48		 0.60
0.52		 40 (0.195)
35 (0.243)		 84 (0.410)
68 (0.472)		 81 (0.395)
41 (0.285)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs3783988 USA (NIMH, NCRAD) AD
CTR		 0.24
0.19		 0.76
0.81		 23 (0.068)
6 (0.021)		 114 (0.337)
93 (0.331)		 201 (0.595)
182 (0.648)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs972725 USA (NIMH, NCRAD) AD
CTR		 0.16
0.23		 0.84
0.77		 3 (0.014)
7 (0.046)		 62 (0.283)
55 (0.364)		 154 (0.703)
89 (0.589)
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AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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