AlzGene

AlzGene - Polymorphism Details

Study:

Carson, 2009

Gene:

RTN3 (ASYIP; HAP; NSPL2; NSPLII; RTN3-A1)

Protein:

reticulon 3 (ASY interacting protein; NSP-like protein II; homolog of ASY protein; isoforme III; isoforme VI; neuroendocrine-specific protein-like 2)

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 16 September 2009

Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs520908	Ireland	AD CTR	0.04 0.02	0.96 0.98	0 (0.000) 0 (0.000)	36 (0.078) 15 (0.044)	423 (0.922) 327 (0.956)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs7943876	Ireland	AD CTR	0.13 0.13	0.87 0.87	7 (0.015) 4 (0.012)	105 (0.225) 80 (0.234)	354 (0.760) 258 (0.754)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	G-Allele	C/C (frequency)	C/G (frequency)	G/G (frequency)
Caucasian
rs7928900	Ireland	AD CTR	0.18 0.17	0.82 0.83	16 (0.034) 8 (0.023)	136 (0.293) 101 (0.293)	312 (0.672) 236 (0.684)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs542998	Ireland	AD CTR	0.22 0.19	0.78 0.81	20 (0.043) 13 (0.038)	164 (0.350) 107 (0.312)	284 (0.607) 223 (0.650)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs10897445	Ireland	AD CTR	0.30 0.31	0.70 0.69	47 (0.101) 29 (0.084)	189 (0.406) 157 (0.456)	230 (0.494) 158 (0.459)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs17657473	Ireland	AD CTR	0.08 0.09	0.92 0.91	6 (0.013) 0 (0.000)	65 (0.139) 59 (0.171)	396 (0.848) 287 (0.829)

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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