AlzGene - Gene overview of all published AD-association studies for A2M
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 Gene: A2M  (CPAMD5; FWP007; S863-7; alpha 2M)  Entrez Gene    View on MSGene   View on PDGene
 Protein: alpha-2-macroglobulin   ProteinLink
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 13 September 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Alvarez, 1999
Spain CL  1  (detail)  190
(-)
C-72 + 9.1
(-)
400
(-)
-Positive
Bagli, 2000
Germany CL  1  (detail)  102
(67%)
C-74.4 + 10.3
(51-101)
191
(52%)
70.6 + 11.4
(50-100)
Negative
Blennow, 2000
Europe (I) CL  1  (detail)  449
(62%)
C-73.1 + 10.4
(-)
349
(44%)
66.7 + 12.5
(-)
Negative
Blennow, 2000
Europe (II) CL  1  (detail)  94
(62%)
N-80.1 + 8.2
(-)
107
(47%)
76.6 + 9.4
(-)
Negative
Blomqvist, 2005
Overlaps with
Emahazion, 2001
CL  1  (detail)  ------n.a.
Blomqvist, 2005
Overlaps with
Prince, 2001
CL  1  (detail)  ------n.a.
Bruno, 2010
Italy CL  1  (detail)  125
(55%)
C-75.4 + 7
(-)
310
(56%)
74.7 + 6.6
(-)
Positive
Bullido, 2000
Spain CL  1  (detail)  154
(60%)
C70.4 + 6.3
(-)
-217
(62%)
72 + 7.6
(-)
Negative
Clarimon, 2003
Spain CL  2  (detail)  112
(73%)
C-76.7 + 5.4
(-)
89
(52%)
74.8 + 5.2
(-)
Negative
Colacicco, 2007
Italy CL  1  (detail)  169
(63%)
C69.5 + 9.7
(-)
69.4 + 5.2
(-)
264
(55%)
71.7 + 7
(-)
Negative
Corder, 2008
Overlaps with
Prince, 2001
CL  1  (detail)  938
(-)
U--397
(-)
-n.a.
Depboylu, 2006
Germany CL  1  (detail)  271
(37%)
C-70.7 + 9.6
(50-95)
280
(31%)
66.9 + 10.6
(50-93)
Positive
Dodel, 2000
USA & Europe CL  1  (detail)  309
(-)
C-72.7 + 9.5
(50-94)
281
(-)
72.9 + 9.4
(51-94)
Positive
Dow, 1999
UK CL  1  (detail)  230
(-)
M--218
(-)
-Negative
Edwards, 2009
USA CL  1  (detail)  296
(-)
M71.7 + 7.8
(-)
79 + 6.6
(-)
566
(-)
73.6 + 6.3
(-)
Negative
Emahazion, 2001
Scotland CL  1  (detail)  121
(-)
C--152
(-)
-Negative
Gibson, 2000
UK CL  2  (detail)  195
(66%)
N-79.8
(57-98)
107
(58%)
79
(60-100)
Trend
Halimi, 2000
France CL  1  (detail)  281
(-)
C-76.9 + 8.3
(-)
84
(-)
77 + 7.4
(-)
Negative
Higuchi, 2000
Unknown    2  (detail)  85
(56%)
N-77.6 + 7.3
(-)
65
(46%)
60.9 + 14.8
(-)
Negative
Janka, 2002
Hungary    1  (detail)  53
(68%)
C69 + 4.2
(-)
73 + 6.2
(-)
51
(73%)
72 + 7
(-)
Negative
Korovaitseva, 1999
Russia CL  1  (detail)  146
(-)
C--160
(-)
-Negative
Koster, 2000
Netherlands PO  2  (detail)  456
(71%)
C76.5 + 6.6
(-)
-358
(58%)
74.5 + 4.4
(-)
Negative
Kovacs, 1999
UK CL  1  (detail)  96
(65%)
N-78.6 + 9.8
(-)
64
(42%)
70.6 + 10.3
(-)
Negative
Mariani, 2006
Italy CL  1  (detail)  100
(74%)
C-76.1 + 7.1
(-)
136
(74%)
72.9 + 7.3
(-)
Negative
McIlroy, 2001
Ireland CL  2  (detail)  219
(67%)
C75.1
(-)
77.5 + 6
(-)
237
(70%)
77.2 + 6.1
(-)
Negative
Myllykangas, 1999
Finland PO  2  (detail)  114
(82%)
M87.2 + 4.4
(-)
89.1 + 2.7
(-)
204
(80%)
88.1 + 2.7
(-)
Positive
Nacmias, 2001
Italy CL  2  (detail)  179
(-)
M66.7 + 6.3
(-)
-98
(-)
74.5 + 25.1
(19-106)
Negative
Nicosia, 2001
Italy CL  1  (detail)  100
(75%)
C-79.2 + 7.3
(-)
49
(63%)
68.3 + 9.2
(-)
Negative
Poduslo, 2002
USA CL  2  (detail)  398
(67%)
M69.4 + 8.5
(44-92)
-216
(-)
-Negative
Prince, 2001
Sweden CL  1  (detail)  204
(61%)
M--186
(58%)
-Negative
Rogaeva, 1999
USA CL  1  (detail)  185
(-)
C--156
(-)
-Negative
Rogaeva, 1999
Canada CL  1  (detail)  207
(-)
C--164
(-)
-Negative
Rudrasingham, 1999
UK CL  1  (detail)  152
(63%)
U71.9 + 8.1
(-)
-99
(55%)
72.6 + 6.6
(-)
Negative
Rudrasingham, 1999
France CL  1  (detail)  616
(63%)
U69.4 + 8.6
(-)
-648
(63%)
73.1 + 8.5
(-)
Negative
Scacchi, 2002
Italy CL  1  (detail)  93
(76%)
C-85.8 + 3.8
(80-95)
157
(59%)
83.9 + 3.1
(80-99)
Negative
Singleton, 1999
UK CL  2  (detail)  213
(64%)
N-79.2 + 0.6
(57-98)
116
(54%)
78.9 + 10.8
(57-100)
Trend
Sleegers, 2004
Netherlands PO  1  (detail)  161
(78%)
C73.4 + 5.3
(-)
76.9 + 5.3
(-)
120
(-)
-Negative
Styczynska, 2003
Poland CL  1  (detail)  100
(66%)
C71 + 4.6
(-)
76.4 + 4.7
(-)
100
(58%)
74.2 + 6.6
(-)
Negative
Wang, 2001
USA CL  2  (detail)  555
(68%)
M71.3 + 6.1
(-)
77.4 + 6.7
(-)
446
(68%)
75.7 + 4.9
(-)
Negative
Wavrant-DeVrieze, 1999
UK CL  1  (detail)  119
(-)
U--114
(-)
-Negative
Wavrant-DeVrieze, 1999
USA (I) CL  1  (detail)  329
(-)
U--487
(-)
-Negative
Wavrant-DeVrieze, 1999
USA (II) CL  1  (detail)  136
(-)
U--145
(-)
-Negative
Wavrant-DeVrieze, 1999
France CL  1  (detail)  616
(-)
U--648
(-)
-Negative
Wehr, 2006
Poland CL  1  (detail)  100
(66%)
C-71.8 + 7.9
(52-91)
144
(53%)
70.5 + 8.8
(47-93)
Negative
Zappia, 2002
Italy CL  1  (detail)  132
(60%)
C-72.3 + 6.4
(-)
184
(55%)
76.6 + 7.5
(-)
Positive
Zappia, 2004
Italy CL  1  (detail)  148
(61%)
C-71.3 + 7.4
(-)
158
(54%)
74.1 + 6.7
(-)
Positive
Zill, 2000
Germany CL  2  (detail)  88
(57%)
C-73 + 9
(-)
118
(53%)
47 + 12
(-)
Negative
 Asian
Bian, 2005
China CL  6  (detail)  216
(-)
C74.7
(-)
-200
(-)
-Negative
Cai, 2005
China    1  (detail)  116
(62%)
U-74.5
(39-91)
271
(56%)
57.8
(33-95)
Negative
Chen, 1999
China CL  1  (detail)  196
(74%)
M-79.5 + 8.5
(-)
180
(66%)
79.2 + 7.5
(-)
Negative
Chen, 2004
China CL,PO  2  (detail)  158
(53%)
C69.4 + 9.4
(-)
-195
(45%)
70 + 7.8
(-)
Trend
Higuchi, 2000
Japan CL  2  (detail)  426
(73%)
C-76.2 + 9
(-)
382
(69%)
74 + 5.6
(-)
Negative
Hu, 1999
Same as Hu, 2000 CL  1  (detail)  ------n.a.
Hu, 2000
Taiwan CL  2  (detail)  82
(-)
C-78.2
(62-96)
110
(-)
79.2
(67-87)
Negative
Jhoo, 2001
Korea CL  1  (detail)  100
(77%)
C68.1 + 8.2
(-)
71.2 + 7.8
(55-85)
203
(78%)
69 + 4.7
(54-83)
Positive
Ki, 2001
Korea CL  1  (detail)  89
(78%)
C73.1 + 5.8
(-)
-50
(58%)
73.2 + 7.8
(-)
Negative
Shibata, 1999
Japan CL  1  (detail)  56
(41%)
C69.2 + 10.2
(-)
72.2 + 9.5
(-)
69
(42%)
71 + 8.1
(-)
Negative
Shibata, 2000
Japan CL  1  (detail)  111
(-)
M-69.6 + 10.4
(-)
95
(-)
69.8 + 9.3
(-)
Negative
Sodeyama, 2000
Japan CL  1  (detail)  62
(-)
N-85.8 + 7.8
(62-104)
90
(-)
85.2 + 7.8
(66-101)
Negative
Song, 2010
China CL  2  (detail)  179
(60%)
C68.2 + 6.5
(-)
-179
(60%)
67.2 + 6.5
(-)
Positive
Tang, 2002
China CL  1  (detail)  114
(61%)
C69.4 + 7.8
(-)
74.6 + 7.5
(39-91)
190
(55%)
55.8 + 15.5
(33-95)
Positive
Yamada, 1999
Overlaps with
Yamada, 2002
CL  1  (detail)  ------n.a.
Yamada, 2002
Japan CL  1  (detail)  82
(-)
N-86.1 + 7.9
(62-104)
119
(-)
85.7 + 8
(65-103)
Negative
 Hispanic
Camelo, 2004
Colombia CL  1  (detail)  83
(72%)
C-69 + 8.9
(-)
69
(72%)
71.4 + 12.3
(-)
Negative
 Other/Mixed
Crawford, 1999
USA CL  1  (detail)  295
(56%)
C73.1 + 6.4
(-)
-113
(62%)
72.7 + 7.7
(-)
Negative
Crawford, 1999
USA CL  1  (detail)  103
(-)
C--83
(-)
-Negative
Liao, 1998
USA & Europe CL  1  (detail)  737
(-)
M--449
(-)
-Positive
Perry, 2001
USA CL  1  (detail)  111
(78%)
M70.8 + 7.8
(-)
71.3 + 7.7
(-)
78
(76%)
75.2 + 7.6
(-)
Negative
Rudrasingham, 1999
USA (I) CL  1  (detail)  143
(62%)
U73.7 + 9.5
(-)
-144
(65%)
77 + 9.2
(-)
Negative
Rudrasingham, 1999
USA (II) CL  1  (detail)  327
(65%)
U75.5 + 9.7
(-)
-487
(67%)
82.7 + 7.5
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Blacker, 1998
USA (NIMH)  1  (detail)  104217
(-)
M--181
(-)
-Positive
Edwards, 2009
Overlaps with
Rogaeva, 1999
 2  (detail)  738-M72.3 + 9.1
(-)
74.8 + 11
(-)
--Positive
Poduslo, 2002
USA  2  (detail)  89181
(-)
M--146
(-)
-Trend
Poduslo, 2002
USA (NIMH)  2  (detail)  1751
(63%)
M68.5 + 4.9
(59-81)
-20
(60%)
77.4 + 6
(66-87)
Positive
Rogaeva, 1999
USA (DUKE)  0  60-C----Negative
Rogaeva, 1999
Canada  0  45-C----Negative
Saunders, 2003
USA (NIMH)  2  (detail)  437-M----Positive
 Hispanic
Romas, 2000
USA, Caribbean  2  (detail)  51100
(-)
C74.4 + 9.5
(42-90)
-47
(-)
-Positive
 Other/Mixed
Rogaeva, 1999
USA (NIMH)  1  (detail)  143-M----Trend
Rudrasingham, 1999
USA (NIMH)  1  (detail)  270-U----Positive
Rudrasingham, 1999
USA (NIA)  1  (detail)  125-U----Trend
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Genes: 695
Polymorphisms: 2973
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