AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs3832852
Back Search Methods Disclaimer Credits
 Polymorphism: rs3832852 (5-bp ins/del)
 Gene: A2M  (CPAMD5; FWP007; S863-7; alpha 2M)  Entrez Gene    View on MSGene   View on PDGene
 Protein: alpha-2-macroglobulin   ProteinLink
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 13 September 2010
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  del-Allele
(frequency)
ins-Allele
(frequency)
del/del
(frequency)
del/ins
(frequency)
ins/ins
(frequency)
 Caucasian 32 AD
CTR
0.17
0.16
0.84
0.84
191 (0.029)
163 (0.027)
1800 (0.272)
1650 (0.270)
4628 (0.699)
4288 (0.703)
 Asian 10 AD
CTR
0.03
0.05
0.97
0.96
2 (0.001)
5 (0.003)
88 (0.065)
141 (0.085)
1274 (0.934)
1522 (0.912)
 Hispanic 2 AD
CTR
0.13
0.07
0.87
0.93
2 (0.011)
1 (0.009)
43 (0.235)
15 (0.129)
138 (0.754)
100 (0.862)
 Other/Mixed 4 AD
CTR
0.16
0.17
0.85
0.84
26 (0.030)
26 (0.032)
220 (0.251)
220 (0.268)
630 (0.719)
576 (0.701)
Total 48 AD
CTR
0.14
0.14
0.86
0.86
221 (0.024)
195 (0.022)
2151 (0.238)
2026 (0.233)
6670 (0.738)
6486 (0.745)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs3832852 (5-bp ins/del)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs10842898
rs1800433
rs1805654
rs226379
rs226380
rs3759277
rs3832852

AlzGene Recent Updates
AlzGene Top Results
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD

The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.