AlzGene - Gene overview of all published AD-association studies for APOC1
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 Gene: APOC1   Entrez Gene    View on MSGene
 Protein: apolipoprotein C-I   ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Chartier-Harlin, 1994
 UK CL  1  (detail)  34
(-)		C57 + 5
(49-64)		-36
(-)		55 + 7.5
(-)		Positive
Chartier-Harlin, 1994
 France    1  (detail)  36
(-)		U78 + 9
(65-91)		-38
(-)		80 + 8
(-)		Negative
Corder, 2006
 Overlaps with
Poduslo, 1998		 CL  1  (detail)  ------n.a.
Li, 2008
 Canada CL  1  (detail)  753
(58%)		C71.9 + 8.5
(-)		77.8 + 8.6
(-)		736
(64%)		73.4 + 7.9
(-)		Positive
Parker, 2005
 Overlaps with
Poduslo, 1998		 CL  1  (detail)  180
(71%)		C70.8 + 8.1
(-)		-141
(59%)		72.3 + 8.4
(51-89)		n.a.
Petit-Turcotte, 2001
 Canada    1  (detail)  142
(-)		N--67
(-)		-Positive
Poduslo, 1995
 Overlaps with
Poduslo, 1998		    1  (detail)  -U----n.a.
Poduslo, 1998
 USA CL  1  (detail)  246
(-)		C69.9 + 8.5
(-)		-289
(57%)		72.6 + 8.2
(-)		Positive
Reiman, 2007
 USA, Netherlands CL  1  (detail)  861
(-)		M-74.9 + 6.6
(-)		550
(-)		77.4 + 7.3
(-)		Positive
Retz, 2001
 Germany CL  1  (detail)  63
(68%)		C66.6 + 11.9
(-)		73.7 + 9.3
(-)		162
(62%)		70.6 + 8.2
(-)		Positive
Scacchi, 1999
 Italy CO  1  (detail)  85
(76%)		C-86.1 + 3.8
(81-95)		156
(58%)		83.8 + 3.2
(74-99)		Positive
Templeton, 1995
 Overlaps with
Chartier-Harlin, 1994 (UK)		 CL  1  (detail)  34
(-)		C57 + 5
(49-64)		-36
(-)		55 + 7.5
(-)		n.a.
Templeton, 1995
 Overlaps with
Chartier-Harlin, 1994 (France)		 CL  1  (detail)  36
(-)		-78 + 9
(65-91)		-38
(-)		80 + 8
(-)		n.a.
Webster, 2010
 Overlaps with
Reiman, 2007		 CL  1  (detail)  861
(-)		M-82.8 + 7.7
(-)		550
(-)		79.7 + 6.3
(-)		n.a. 
Yu, 2007
 USA CL  1  (detail)  193
(53%)		C--232
(59%)		-Positive
 African Descent
Tycko, 2004
 USA CL  1  (detail)  142
(-)		C--251
(-)		-Negative
 Asian
Kamino, 1996
 Japan CL  1  (detail)  99
(-)		C75.4 + 7
(65-93)		-52
(-)		88.2 + 5.4
(80-101)		Positive
Ki, 2002
 Korea CL  1  (detail)  120
(76%)		C69.7 + 6.2
(-)		73.8 + 6.5
(-)		132
(76%)		70.2 + 7.1
(-)		Positive
Shi, 2004
 China CL  1  (detail)  257
(60%)		C73.3 + 8.3
(-)		76.7 + 8.8
(58-98)		242
(53%)		80 + 7.6
(59-99)		Positive
Takei, 2009
 Japan CL  7  (detail)  547
(72%)		C73 + 6.9
(60-93)		-715
(54%)		73 + 6.8
(-)		Positive
Yang, 2003
 China CL  1  (detail)  183
(58%)		C-74.6
(-)		133
(48%)		74.5
(-)		Trend
 Hispanic
Tycko, 2004
 USA CL  1  (detail)  230
(-)		C--359
(-)		-Positive
 Other/Mixed
Coon, 2007
 Overlaps with
Reiman, 2007		 CL  1  (detail)  664
(55%)		N-82 + 7.7
(-)		422
(60%)		79 + 11
(-)		Positive
Drigalenko, 1998
 Unknown CL  1  (detail)  176
(66%)		C--226
(56%)		-Positive
Mullan, 1996
 USA PO  1  (detail)  214
(-)		C73 + 8
(-)		-496
(-)		74 + 8
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Bertram, 2008
 GWAS  1  (detail)  410941
(69%)		M72.3 + 7.7
(50-97)		-404
(58%)		70 + 10.7
(31-93)		Positive
Poduslo, 1995
 USA  1  (detail)  20-U----Negative
 Other/Mixed
Mullan, 1996
 USA  1  (detail)  2540
(-)		U74 + 10.4
(-)		-64
(-)		74.8 + 6.7
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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