AlzGene

Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs2282649

Polymorphism:

rs2282649

Gene:

SORL1 (GP250; LR11; LRP9; SorLA; SorLA-1)

Protein:

Sortilin-related receptor (Sorting protein-related receptor containing LDLR class A repeats; SorLA; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11)

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		T-Allele (frequency)	C-Allele (frequency)	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian	15	AD CTR	0.29 0.30	0.71 0.70	487 (0.084) 1022 (0.090)	2378 (0.411) 4698 (0.414)	2927 (0.505) 5632 (0.496)
African Descent	1	AD CTR	0.11 0.17	0.89 0.84	1 (0.011) 4 (0.025)	17 (0.193) 44 (0.278)	70 (0.795) 110 (0.696)
Asian	3	AD CTR	0.55 0.49	0.45 0.51	239 (0.291) 205 (0.243)	426 (0.518) 420 (0.498)	157 (0.191) 219 (0.259)
Hispanic	1	AD CTR	0.28 0.28	0.72 0.72	14 (0.079) 15 (0.077)	72 (0.404) 78 (0.402)	92 (0.517) 101 (0.521)
Other/Mixed	1	AD CTR	0.27 0.27	0.73 0.74	11 (0.101) 7 (0.062)	37 (0.339) 46 (0.407)	61 (0.560) 60 (0.531)
Total	21	AD CTR	0.32 0.31	0.68 0.69	752 (0.108) 1253 (0.099)	2930 (0.419) 5286 (0.418)	3307 (0.473) 6122 (0.484)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs2282649

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs10502262
rs11218301
rs11218322
rs11218347
rs1131497
rs11501162
rs11600875
rs11601559
rs11605969
rs12287339
rs1503415
rs1532763
rs1614735
rs1620003
rs1629493
rs1699105
rs1790213
rs2101756
rs2276412
rs2298525
rs3781827
rs3781832
rs3781834
rs3781835
rs3824966
rs4420280
rs4631890
rs4936632
rs4936637
rs560573
rs578506
rs666004
rs676759
rs7101373
rs7116734
rs7124060
rs726601
rs7945931
SORL1-ex26

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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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