AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs2373115
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 Polymorphism: rs2373115
 Gene: GAB2   Entrez Gene
 Protein: GRB2-associated binding protein 2  (Grb2-associated binder 2)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 G-Allele
(frequency)		 T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian 10 AD
CTR		 0.16
0.18		 0.85
0.82		 107 (0.023)
145 (0.035)		 1214 (0.264)
1218 (0.291)		 3284 (0.713)
2818 (0.674)
 Asian 2 AD
CTR		 0.44
0.45		 0.57
0.55		 382 (0.199)
372 (0.199)		 906 (0.472)
925 (0.494)		 631 (0.329)
575 (0.307)
Total 12 AD
CTR		 0.24
0.26		 0.76
0.74		 489 (0.075)
517 (0.085)		 2120 (0.325)
2143 (0.354)		 3915 (0.600)
3393 (0.561)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs2373115

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs10501426
rs10899469
rs10899496
rs11237451
rs11601726
rs11603112
rs1318241
rs1893447
rs1981405
rs2292572
rs2450129
rs2450135
rs2511175
rs2511188
rs4944196
rs6592772
rs7107174
rs7112234
rs731600
rs7927923
rs7941639

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3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.