AlzGene - Gene overview of all published AD-association studies for GAB2
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 Gene: GAB2   Entrez Gene
 Protein: GRB2-associated binding protein 2  (Grb2-associated binder 2)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Chapuis, 2008
France (I) CL  1  (detail)  770
(64%)
C69.5 + 7.4
(-)
73 + 8.4
(-)
659
(64%)
73.1 + 8.5
(-)
Trend
Chapuis, 2008
France (II) CL  1  (detail)  573
(62%)
C64.9 + 9.8
(-)
69.3 + 8.8
(-)
580
(54%)
66.3 + 10.6
(-)
Trend
Chapuis, 2008
UK CL  1  (detail)  416
(57%)
C-74.8 + 7.1
(-)
167
(62%)
71.2 + 7.3
(-)
Trend
Feulner, 2009
Germany CL  22  (detail)  491
(57%)
C-72.2
(-)
479
(46%)
39.5
(-)
Positive
Harold, 2009
GWAS (Stage 1) CL  3  (detail)  3941
(63%)
M72.7
(-)
79
(-)
7848
(53%)
55.6
(-)
Negative
Ikram, 2008
Netherlands PO  22  (detail)  443
(-)
---5064
(-)
-Positive
Li, 2008
Canada CL  10  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Nacmias, 2009
Italy CL  1  (detail)  241
(63%)
C72.4 + 4.4
(-)
-338
(70%)
84.2 + 18.2
(-)
Positive
Ramirez-Lorca, 2009
Spain CL  1  (detail)  521
(-)
C--597
(-)
-Negative
Reiman, 2007
USA, Netherlands (discovery) CL  10  (detail)  446
(-)
N-73.5 + 6.2
(-)
290
(-)
75.8 + 7.5
(-)
Positive
Reiman, 2007
USA, Netherlands (replication) CL  10  (detail)  197
(-)
N-73.5 + 6.2
(-)
114
(-)
75.8 + 7.5
(-)
Positive
Reiman, 2007
USA (MCR) CL  10  (detail)  218
(-)
C-78.9 + 7.8
(-)
146
(-)
81.7 + 6.6
(-)
Positive
Sleegers, 2008
Belgium CL  10  (detail)  528
(70%)
C79 + 5.2
(-)
-601
(57%)
61.9 + 15.3
(-)
Positive
 Asian
Lin, 2009
China CL  2  (detail)  292
(74%)
C75.7 + 9.2
(-)
79.6 + 9.5
(-)
227
(69%)
76 + 8.9
(-)
Negative
Miyashita, 2008
Japan CL  10  (detail)  1656
(72%)
C73.1 + 6.2
(60-85)
-1656
(59%)
75.3 + 6.1
(64-96)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Schjeide, 2009
USA (NIMH)  1  (detail)  410941
(-)
M72.3 + 7.7
(50-97)
-404
(-)
70 + 10.7
(31-93)
Positive
Schjeide, 2009
USA (NIA)  1  (detail)  329748
(-)
M74.2 + 7.1
(52-98)
-282
(-)
73.4 + 9.6
(36-94)
Negative
Schjeide, 2009
USA (NCRAD)  1  (detail)  331799
(-)
M71.3 + 7.6
(50-98)
-293
(-)
70.6 + 8.1
(39-93)
Positive
Schjeide, 2009
USA (CAG)  1  (detail)  215220
(-)
M69.3 + 9
(50-89)
-263
(-)
73.3 + 8.6
(50-92)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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