AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Koelsch, 2009
 Gene: CYP46A1  (CP46; CYP46)  Entrez Gene
 Protein: cytochrome P450, family 46, subfamily A, polypeptide 1   ProteinLink
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 16

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs754203 (2i) Germany AD
CTR		 0.29
0.29		 0.71
0.71		 23 (0.085)
13 (0.081)		 111 (0.411)
66 (0.413)		 136 (0.504)
81 (0.506)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4900442 (3i) Germany AD
CTR		 0.46
0.49		 0.54
0.51		 66 (0.196)
44 (0.242)		 177 (0.525)
91 (0.500)		 94 (0.279)
47 (0.258)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7157609 Germany AD
CTR		 0.31
0.35		 0.69
0.65		 36 (0.080)
44 (0.135)		 210 (0.465)
139 (0.426)		 206 (0.456)
143 (0.439)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs943881 Germany AD
CTR		 0.39
0.37		 0.61
0.63		 41 (0.152)
22 (0.137)		 128 (0.476)
75 (0.466)		 100 (0.372)
64 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs943880 Germany AD
CTR		 0.39
0.37		 0.61
0.63		 41 (0.152)
22 (0.137)		 128 (0.476)
75 (0.466)		 100 (0.372)
64 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   AG-Allele del-Allele AG/AG
(frequency)		 AG/del
(frequency)		 del/del
(frequency)
 Caucasian
rs34779504 Germany AD
CTR		 0.15
0.15		 0.85
0.85		 6 (0.022)
4 (0.025)		 69 (0.256)
41 (0.255)		 195 (0.722)
116 (0.720)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2146238 Germany AD
CTR		 0.16
0.14		 0.84
0.86		 7 (0.026)
3 (0.019)		 73 (0.269)
39 (0.244)		 191 (0.705)
118 (0.738)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2273839 Germany AD
CTR		 0.41
0.38		 0.59
0.62		 45 (0.167)
23 (0.144)		 131 (0.485)
75 (0.469)		 94 (0.348)
62 (0.388)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs36018216 Germany AD
CTR		 0.39
0.37		 0.61
0.63		 41 (0.152)
22 (0.137)		 128 (0.476)
75 (0.466)		 100 (0.372)
64 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs3752958 Germany AD
CTR		 0.10
0.12		 0.90
0.88		 3 (0.011)
2 (0.013)		 49 (0.181)
34 (0.213)		 219 (0.808)
124 (0.775)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs8022722 Germany AD
CTR		 0.30
0.30		 0.70
0.70		 24 (0.089)
14 (0.088)		 113 (0.420)
67 (0.421)		 132 (0.491)
78 (0.491)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs911913 Germany AD
CTR		 0.15
0.17		 0.85
0.83		 6 (0.022)
5 (0.031)		 69 (0.256)
45 (0.281)		 195 (0.722)
110 (0.688)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
CYP46A1_IVS9+293T/A Germany AD
CTR		 0.06
0.08		 0.94
0.92		 1 (0.004)
1 (0.006)		 30 (0.111)
24 (0.150)		 239 (0.885)
135 (0.844)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2295911 Germany AD
CTR		 0.17
0.17		 0.83
0.83		 8 (0.030)
5 (0.031)		 76 (0.281)
45 (0.281)		 186 (0.689)
110 (0.688)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2273840 Germany AD
CTR		 0.07
0.06		 0.93
0.94		 1 (0.004)
1 (0.006)		 35 (0.130)
18 (0.113)		 234 (0.867)
141 (0.881)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   ins-Allele del-Allele ins/ins
(frequency)		 ins/del
(frequency)		 del/del
(frequency)
 Caucasian
rs3830998 Germany AD
CTR		 0.30
0.30		 0.70
0.70		 24 (0.089)
14 (0.088)		 113 (0.420)
67 (0.421)		 132 (0.491)
78 (0.491)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.