AlzGene - Polymorphism Details
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 Study: Feulner, 2009
 Gene: ACE  (DCP; DCP1; CD143; MGC26566; ACE1)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1   ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 14

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4343 (ACE3) Germany AD
CTR		 0.52
0.51		 0.48
0.49		 135 (0.275)
125 (0.261)		 238 (0.485)
239 (0.499)		 118 (0.240)
115 (0.240)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4362 (ACE2) Germany AD
CTR		 0.51
0.51		 0.49
0.49		 130 (0.264)
126 (0.263)		 241 (0.490)
238 (0.497)		 121 (0.246)
115 (0.240)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4309 (ACE5) Germany AD
CTR		 0.44
0.44		 0.56
0.56		 94 (0.191)
91 (0.190)		 241 (0.491)
240 (0.502)		 156 (0.318)
147 (0.308)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4311 Germany AD
CTR		 0.47
0.47		 0.53
0.53		 114 (0.233)
106 (0.221)		 233 (0.476)
239 (0.499)		 143 (0.292)
134 (0.280)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4329 Germany AD
CTR		 0.48
0.48		 0.52
0.52		 114 (0.233)
113 (0.236)		 238 (0.486)
238 (0.497)		 138 (0.282)
128 (0.267)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs4267385 Germany AD
CTR		 0.43
0.41		 0.57
0.59		 87 (0.177)
76 (0.159)		 246 (0.501)
240 (0.502)		 158 (0.322)
162 (0.339)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4353 Germany AD
CTR		 0.48
0.49		 0.52
0.51		 117 (0.238)
116 (0.242)		 243 (0.494)
235 (0.491)		 132 (0.268)
128 (0.267)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12451328 Germany AD
CTR		 0.39
0.41		 0.61
0.59		 69 (0.141)
76 (0.159)		 241 (0.491)
242 (0.506)		 181 (0.369)
160 (0.335)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4305 Germany AD
CTR		 0.44
0.42		 0.56
0.58		 97 (0.197)
90 (0.188)		 241 (0.490)
220 (0.459)		 154 (0.313)
169 (0.353)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4459609 Germany AD
CTR		 0.38
0.37		 0.62
0.63		 76 (0.155)
73 (0.152)		 221 (0.450)
209 (0.436)		 194 (0.395)
197 (0.411)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4461142 Germany AD
CTR		 0.47
0.48		 0.53
0.52		 109 (0.222)
114 (0.238)		 244 (0.498)
236 (0.493)		 137 (0.280)
129 (0.269)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs8066276 Germany AD
CTR		 0.38
0.37		 0.62
0.63		 68 (0.138)
59 (0.123)		 242 (0.493)
234 (0.489)		 181 (0.369)
186 (0.388)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs867640 Germany AD
CTR		 0.39
0.37		 0.61
0.63		 69 (0.141)
60 (0.125)		 242 (0.493)
231 (0.482)		 180 (0.367)
188 (0.392)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs9914151 Germany AD
CTR		 0.41
0.44		 0.59
0.56		 79 (0.161)
90 (0.188)		 248 (0.505)
240 (0.501)		 164 (0.334)
149 (0.311)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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