AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Li, 2008
 Gene: ADAM10  (kuz; HsT18717; kuzbanian; MADM)  Entrez Gene
 Protein: a disintegrin and metalloproteinase domain 10   ProteinLink
 Chromosome: 15   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 46

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs6494031 Canada AD
CTR		 0.11
0.14		 0.89
0.86		 10 (0.014)
19 (0.028)		 129 (0.187)
148 (0.216)		 551 (0.799)
518 (0.756)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs605928 Canada AD
CTR		 0.28
0.32		 0.72
0.68		 62 (0.090)
73 (0.107)		 257 (0.371)
296 (0.434)		 373 (0.539)
313 (0.459)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7161889 Canada AD
CTR		 0.31
0.37		 0.69
0.63		 65 (0.101)
72 (0.117)		 272 (0.424)
315 (0.511)		 305 (0.475)
230 (0.373)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs16940602 Canada AD
CTR		 0.03
0.02		 0.97
0.98		 0 (0.000)
0 (0.000)		 37 (0.061)
24 (0.038)		 571 (0.939)
602 (0.962)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs16940751 Canada AD
CTR		 0.00
0.00		 1.00
1.00		 0 (0.000)
0 (0.000)		 3 (0.004)
3 (0.004)		 681 (0.996)
670 (0.996)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1979178 Canada AD
CTR		 0.00
0.00		 1.00
1.00		 0 (0.000)
0 (0.000)		 0 (0.000)
2 (0.003)		 690 (1.000)
682 (0.997)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs16940629 Canada AD
CTR		 0.00
0.00		 1.00
1.00		 0 (0.000)
0 (0.000)		 1 (0.001)
1 (0.001)		 690 (0.999)
686 (0.999)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs6494025 Canada AD
CTR		 0.03
0.03		 0.97
0.97		 3 (0.004)
1 (0.001)		 31 (0.045)
36 (0.053)		 655 (0.951)
646 (0.946)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs16940571 Canada AD
CTR		 0.03
0.03		 0.97
0.97		 3 (0.004)
1 (0.001)		 29 (0.042)
35 (0.051)		 664 (0.954)
649 (0.947)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs12901512 Canada AD
CTR		 0.02
0.02		 0.98
0.98		 0 (0.000)
0 (0.000)		 28 (0.044)
23 (0.036)		 608 (0.956)
619 (0.964)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10518984 Canada AD
CTR		 0.04
0.04		 0.96
0.96		 1 (0.001)
0 (0.000)		 47 (0.068)
51 (0.075)		 644 (0.931)
631 (0.925)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs16940712 Canada AD
CTR		 0.03
0.03		 0.97
0.97		 0 (0.000)
0 (0.000)		 44 (0.063)
47 (0.068)		 653 (0.937)
645 (0.932)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4775085 (rs7402779) Canada AD
CTR		 0.05
0.05		 0.95
0.95		 1 (0.002)
0 (0.000)		 63 (0.097)
69 (0.105)		 584 (0.901)
587 (0.895)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs16940472 Canada AD
CTR		 0.11
0.11		 0.89
0.89		 7 (0.010)
9 (0.013)		 143 (0.209)
137 (0.202)		 533 (0.780)
532 (0.785)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs17269348 Canada AD
CTR		 0.13
0.13		 0.87
0.87		 12 (0.020)
10 (0.017)		 133 (0.223)
138 (0.232)		 452 (0.757)
447 (0.751)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8036097 Canada AD
CTR		 0.14
0.15		 0.86
0.85		 19 (0.028)
13 (0.020)		 155 (0.231)
175 (0.263)		 498 (0.741)
477 (0.717)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2414607 Canada AD
CTR		 0.15
0.16		 0.85
0.84		 13 (0.020)
10 (0.016)		 169 (0.262)
182 (0.293)		 464 (0.718)
429 (0.691)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7174210 Canada AD
CTR		 0.15
0.13		 0.85
0.87		 13 (0.019)
11 (0.017)		 170 (0.254)
145 (0.220)		 486 (0.726)
503 (0.763)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs7164844 Canada AD
CTR		 0.14
0.15		 0.86
0.85		 13 (0.019)
11 (0.016)		 164 (0.236)
184 (0.266)		 519 (0.746)
497 (0.718)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12437457 Canada AD
CTR		 0.11
0.14		 0.89
0.86		 13 (0.019)
22 (0.032)		 129 (0.185)
148 (0.214)		 555 (0.796)
522 (0.754)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8029805 Canada AD
CTR		 0.11
0.14		 0.89
0.86		 12 (0.018)
20 (0.030)		 124 (0.184)
144 (0.215)		 539 (0.799)
507 (0.756)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs16940651 Canada AD
CTR		 0.12
0.14		 0.88
0.86		 13 (0.019)
22 (0.032)		 135 (0.194)
151 (0.218)		 549 (0.788)
519 (0.750)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs6494030 Canada AD
CTR		 0.12
0.14		 0.88
0.86		 13 (0.019)
22 (0.032)		 138 (0.198)
154 (0.223)		 546 (0.783)
516 (0.746)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs664936 Canada AD
CTR		 0.21
0.20		 0.79
0.80		 30 (0.045)
29 (0.043)		 225 (0.334)
207 (0.309)		 418 (0.621)
433 (0.647)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs10851639 Canada AD
CTR		 0.22
0.21		 0.78
0.79		 41 (0.059)
35 (0.051)		 221 (0.318)
224 (0.326)		 432 (0.622)
428 (0.623)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7166325 Canada AD
CTR		 0.12
0.14		 0.88
0.86		 13 (0.019)
23 (0.034)		 133 (0.196)
147 (0.217)		 531 (0.784)
508 (0.749)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11071397 Canada AD
CTR		 0.14
0.18		 0.86
0.82		 15 (0.024)
22 (0.036)		 147 (0.239)
169 (0.279)		 454 (0.737)
415 (0.685)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs12913383 Canada AD
CTR		 0.13
0.16		 0.87
0.84		 17 (0.024)
28 (0.041)		 151 (0.217)
167 (0.242)		 529 (0.759)
495 (0.717)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1869133 Canada AD
CTR		 0.23
0.23		 0.77
0.77		 37 (0.053)
39 (0.056)		 242 (0.347)
244 (0.353)		 418 (0.600)
409 (0.591)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12324536 Canada AD
CTR		 0.19
0.19		 0.81
0.81		 21 (0.030)
24 (0.035)		 219 (0.318)
214 (0.314)		 449 (0.652)
443 (0.651)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs17269341 Canada AD
CTR		 0.18
0.19		 0.82
0.81		 25 (0.039)
30 (0.047)		 189 (0.292)
181 (0.281)		 433 (0.669)
432 (0.672)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs3751542 Canada AD
CTR		 0.30
0.29		 0.70
0.71		 67 (0.098)
65 (0.096)		 271 (0.398)
266 (0.393)		 343 (0.504)
345 (0.510)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs690 Canada AD
CTR		 0.43
0.42		 0.57
0.58		 113 (0.162)
124 (0.179)		 366 (0.526)
338 (0.488)		 217 (0.312)
230 (0.332)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs17190678 Canada AD
CTR		 0.47
0.48		 0.53
0.52		 152 (0.223)
158 (0.234)		 334 (0.490)
331 (0.490)		 196 (0.287)
187 (0.277)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8028759 Canada AD
CTR		 0.32
0.31		 0.68
0.69		 68 (0.098)
66 (0.097)		 304 (0.440)
289 (0.424)		 319 (0.462)
327 (0.479)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11071386 Canada AD
CTR		 0.35
0.36		 0.65
0.64		 76 (0.113)
81 (0.122)		 316 (0.468)
315 (0.474)		 283 (0.419)
268 (0.404)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8035006 Canada AD
CTR		 0.31
0.31		 0.69
0.69		 63 (0.097)
65 (0.101)		 274 (0.423)
266 (0.414)		 310 (0.479)
312 (0.485)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11071385 Canada AD
CTR		 0.19
0.20		 0.81
0.80		 19 (0.028)
25 (0.038)		 220 (0.328)
209 (0.315)		 432 (0.644)
430 (0.648)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1968687 Canada AD
CTR		 0.10
0.11		 0.90
0.89		 6 (0.009)
8 (0.012)		 127 (0.182)
138 (0.199)		 563 (0.809)
546 (0.789)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1968689 Canada AD
CTR		 0.07
0.08		 0.93
0.92		 5 (0.007)
5 (0.007)		 86 (0.124)
102 (0.150)		 600 (0.868)
575 (0.843)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11639204 Canada AD
CTR		 0.01
0.02		 0.99
0.98		 0 (0.000)
1 (0.001)		 19 (0.028)
21 (0.031)		 665 (0.972)
657 (0.968)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2414598 Canada AD
CTR		 0.01
0.02		 0.99
0.98		 0 (0.000)
0 (0.000)		 19 (0.027)
22 (0.032)		 673 (0.973)
659 (0.968)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2414599 Canada AD
CTR		 0.02
0.02		 0.98
0.98		 0 (0.000)
0 (0.000)		 20 (0.030)
24 (0.037)		 636 (0.970)
627 (0.963)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7179747 Canada AD
CTR		 0.01
0.02		 0.99
0.98		 0 (0.000)
0 (0.000)		 20 (0.029)
24 (0.035)		 674 (0.971)
664 (0.965)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7180130 Canada AD
CTR		 0.01
0.02		 0.99
0.98		 0 (0.000)
0 (0.000)		 18 (0.026)
23 (0.034)		 666 (0.974)
659 (0.966)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11857405 Canada AD
CTR		 0.00
0.00		 1.00
1.00		 0 (0.000)
0 (0.000)		 1 (0.001)
1 (0.001)		 696 (0.999)
691 (0.999)
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.