Updated 18 April 2011 ; Because of the complete correlation between genetic markers in MAPT and STH, these two loci have been combined for display in this database
Total number of polymorphisms investigated by this study: 2
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID# (Link to NCBI)
Population
H2-Allele
H1-Allele
H2/H2 (frequency)
H2/H1 (frequency)
H1/H1 (frequency)
Other/Mixed
MAPT_H1H2
USA
AD CTR
0.47 0.46
0.53 0.54
48 (0.127) 18 (0.125)
261 (0.692) 97 (0.674)
68 (0.180) 29 (0.201)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID# (Link to NCBI)
Population
A-Allele
B-Allele
A/A (frequency)
A/B (frequency)
B/B (frequency)
Other/Mixed
H47Y (AflIII)
USA
AD CTR
0.14 0.15
0.86 0.85
5 (0.019) 3 (0.021)
65 (0.245) 37 (0.261)
195 (0.736) 102 (0.718)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.