AlzGene

AlzGene - Polymorphism Details

Study:

Wollmer, 2007

Gene:

FDPS (FPS)

Protein:

farnesyl diphosphate synthase

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs11264359	Belgium	AD CTR	0.24 0.26	0.76 0.74	36 (0.050) 32 (0.070)	272 (0.380) 173 (0.376)	408 (0.570) 255 (0.554)
rs11264359	Germany	AD CTR	0.18 0.21	0.83 0.79	3 (0.075) 2 (0.028)	8 (0.200) 26 (0.366)	29 (0.725) 43 (0.606)
rs11264359	Greece	AD CTR	0.23 0.20	0.77 0.80	19 (0.073) 2 (0.021)	83 (0.319) 33 (0.351)	158 (0.608) 59 (0.628)
rs11264359	Poland	AD CTR	0.24 0.21	0.76 0.79	12 (0.056) 13 (0.057)	81 (0.375) 70 (0.308)	123 (0.569) 144 (0.634)
rs11264359	Sweden	AD CTR	0.24 0.25	0.76 0.75	4 (0.022) 14 (0.088)	79 (0.427) 53 (0.333)	102 (0.551) 92 (0.579)
rs11264359	Switzerland	AD CTR	0.27 0.28	0.73 0.72	8 (0.057) 16 (0.080)	59 (0.421) 81 (0.405)	73 (0.521) 103 (0.515)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	T-Allele	G/G (frequency)	G/T (frequency)	T/T (frequency)
Caucasian
rs11264361	Belgium	AD CTR	0.22 0.24	0.78 0.76	29 (0.040) 24 (0.053)	262 (0.365) 165 (0.367)	427 (0.595) 261 (0.580)
rs11264361	Germany	AD CTR	0.15 0.20	0.85 0.80	3 (0.075) 2 (0.028)	6 (0.150) 25 (0.347)	31 (0.775) 45 (0.625)
rs11264361	Greece	AD CTR	0.21 0.19	0.79 0.81	15 (0.056) 2 (0.021)	82 (0.306) 33 (0.340)	171 (0.638) 62 (0.639)
rs11264361	Poland	AD CTR	0.23 0.22	0.77 0.78	12 (0.056) 13 (0.055)	77 (0.356) 80 (0.336)	127 (0.588) 145 (0.609)
rs11264361	Sweden	AD CTR	0.22 0.25	0.78 0.75	4 (0.022) 12 (0.073)	75 (0.405) 57 (0.348)	106 (0.573) 95 (0.579)
rs11264361	Switzerland	AD CTR	0.26 0.26	0.74 0.74	8 (0.056) 13 (0.064)	59 (0.413) 79 (0.387)	76 (0.531) 112 (0.549)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	A-Allele	C/C (frequency)	C/A (frequency)	A/A (frequency)
Caucasian
rs2297480	Belgium	AD CTR	0.22 0.24	0.78 0.76	31 (0.043) 28 (0.061)	256 (0.358) 165 (0.358)	429 (0.599) 268 (0.581)
rs2297480	Germany	AD CTR	0.16 0.20	0.84 0.80	3 (0.075) 2 (0.028)	7 (0.175) 25 (0.352)	30 (0.750) 44 (0.620)
rs2297480	Greece	AD CTR	0.20 0.19	0.80 0.81	14 (0.052) 2 (0.021)	81 (0.302) 33 (0.344)	173 (0.646) 61 (0.635)
rs2297480	Poland	AD CTR	0.23 0.22	0.77 0.78	11 (0.050) 13 (0.055)	78 (0.358) 78 (0.329)	129 (0.592) 146 (0.616)
rs2297480	Sweden	AD CTR	0.22 0.23	0.78 0.77	3 (0.016) 11 (0.069)	75 (0.405) 52 (0.325)	107 (0.578) 97 (0.606)
rs2297480	Switzerland	AD CTR	0.26 0.26	0.74 0.74	7 (0.050) 13 (0.063)	58 (0.417) 80 (0.390)	74 (0.532) 112 (0.546)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		min-Allele	maj-Allele	min/min (frequency)	min/maj (frequency)	maj/maj (frequency)
Caucasian
rs4971072	Switzerland	AD CTR	- -	- -	0 (-) 0 (-)	0 (-) 0 (-)	0 (-) 0 (-)

(-) : Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

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