AlzGene

AlzGene - Polymorphism Details

Study:

Carrasquillo, 2010

Gene:

IDE (INSULYSIN)

View on PDGene

Protein:

insulin-degrading enzyme (insulysin; insulinase)

Chromosome:

10 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 17

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	T-Allele	A/A (frequency)	A/T (frequency)	T/T (frequency)
Caucasian
rs4646958 (IDE8)	USA & Europe	AD CTR	0.08 0.10	0.92 0.90	24 (0.010) 19 (0.007)	375 (0.150) 471 (0.178)	2101 (0.840) 2156 (0.815)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs4646957	USA & Europe	AD CTR	0.35 0.36	0.65 0.64	416 (0.121) 418 (0.126)	1575 (0.459) 1530 (0.459)	1440 (0.420) 1382 (0.415)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs4646955	USA & Europe	AD CTR	0.26 0.25	0.74 0.75	238 (0.069) 224 (0.066)	1286 (0.373) 1236 (0.363)	1928 (0.559) 1948 (0.572)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs11187060	USA & Europe	AD CTR	0.33 0.34	0.67 0.66	256 (0.104) 286 (0.109)	1095 (0.444) 1221 (0.463)	1116 (0.452) 1128 (0.428)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	A-Allele	T/T (frequency)	T/A (frequency)	A/A (frequency)
Caucasian
rs7895832	USA & Europe	AD CTR	0.08 0.09	0.92 0.91	19 (0.008) 16 (0.006)	353 (0.143) 450 (0.170)	2099 (0.849) 2175 (0.824)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	G-Allele	T/T (frequency)	T/G (frequency)	G/G (frequency)
Caucasian
IDE_SNP309 (exon 13)	USA & Europe	AD CTR	0.02 0.02	0.98 0.98	3 (0.001) 1 (0.000)	117 (0.047) 89 (0.034)	2344 (0.951) 2538 (0.966)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
IDE_SNP310 (intron 12)	USA & Europe	AD CTR	0.02 0.02	0.98 0.98	0 (0.000) 0 (0.000)	120 (0.034) 113 (0.034)	3363 (0.966) 3251 (0.966)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		del-Allele	ins-Allele	del/del (frequency)	del/ins (frequency)	ins/ins (frequency)
Caucasian
IDE_variantID-2 (2bp-indel)	USA & Europe	AD CTR	0.02 0.02	0.98 0.98	3 (0.001) 3 (0.001)	157 (0.045) 130 (0.038)	3343 (0.954) 3297 (0.961)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs11187061	USA & Europe	AD CTR	0.19 0.18	0.81 0.82	141 (0.041) 120 (0.035)	1059 (0.305) 1009 (0.297)	2268 (0.654) 2263 (0.667)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	C-Allele	G/G (frequency)	G/C (frequency)	C/C (frequency)
Caucasian
rs11187074	USA & Europe	AD CTR	0.19 0.18	0.81 0.82	99 (0.041) 86 (0.034)	725 (0.300) 748 (0.294)	1594 (0.659) 1714 (0.673)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs17107721	USA & Europe	AD CTR	0.05 0.05	0.95 0.95	11 (0.003) 7 (0.002)	301 (0.087) 324 (0.096)	3131 (0.909) 3045 (0.902)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs17107734	USA & Europe	AD CTR	0.08 0.09	0.92 0.91	19 (0.008) 16 (0.006)	358 (0.145) 445 (0.170)	2086 (0.847) 2160 (0.824)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs17445328	USA & Europe	AD CTR	0.25 0.25	0.75 0.75	164 (0.067) 163 (0.064)	913 (0.373) 953 (0.373)	1368 (0.560) 1439 (0.563)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs17875327	USA & Europe	AD CTR	0.10 0.10	0.90 0.90	34 (0.010) 23 (0.007)	629 (0.181) 658 (0.193)	2806 (0.809) 2728 (0.800)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		ins-Allele	del-Allele	ins/ins (frequency)	ins/del (frequency)	del/del (frequency)
Caucasian
rs5786996 (1bp-indel)	USA & Europe	AD CTR	0.03 0.04	0.97 0.96	5 (0.001) 1 (0.000)	228 (0.065) 277 (0.081)	3287 (0.934) 3142 (0.919)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		ins-Allele	del-Allele	ins/ins (frequency)	ins/del (frequency)	del/del (frequency)
Caucasian
rs5786997 (2bp-indel)	USA & Europe	AD CTR	0.10 0.11	0.90 0.89	5 (0.002) 39 (0.012)	620 (0.187) 643 (0.192)	2685 (0.811) 2666 (0.796)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs6583817	USA & Europe	AD CTR	0.12 0.13	0.88 0.87	52 (0.015) 55 (0.016)	698 (0.205) 787 (0.232)	2659 (0.780) 2557 (0.752)

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