AlzGene - Polymorphism Details
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 Study: Reitz, 2010
 Gene: IDE  (INSULYSIN)  Entrez Gene    View on PDGene
 Protein: insulin-degrading enzyme  (insulysin; insulinase)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 14

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Hispanic
rs1887922 USA AD
CTR		 0.18
0.17		 0.82
0.83		 5 (0.031)
8 (0.027)		 47 (0.294)
83 (0.282)		 108 (0.675)
203 (0.690)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Hispanic
rs2149632 (IDE_12) USA AD
CTR		 0.23
0.23		 0.77
0.77		 8 (0.050)
16 (0.054)		 57 (0.356)
104 (0.354)		 95 (0.594)
174 (0.592)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs2421943 (IDE_17) USA AD
CTR		 0.32
0.32		 0.68
0.68		 16 (0.103)
30 (0.103)		 68 (0.436)
126 (0.434)		 72 (0.462)
134 (0.462)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Hispanic
rs4646957 USA AD
CTR		 0.44
0.47		 0.56
0.53		 31 (0.194)
65 (0.222)		 79 (0.494)
146 (0.498)		 50 (0.313)
82 (0.280)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Hispanic
rs11187060 USA AD
CTR		 0.34
0.34		 0.66
0.66		 18 (0.113)
34 (0.116)		 72 (0.450)
132 (0.449)		 70 (0.438)
128 (0.435)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Hispanic
rs11187064 USA AD
CTR		 0.18
0.18		 0.82
0.82		 5 (0.031)
10 (0.034)		 47 (0.294)
87 (0.295)		 108 (0.675)
198 (0.671)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs1999763 USA AD
CTR		 0.11
0.11		 0.89
0.89		 2 (0.013)
4 (0.014)		 31 (0.194)
58 (0.197)		 127 (0.794)
233 (0.790)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Hispanic
rs7100623 USA AD
CTR		 0.18
0.17		 0.82
0.83		 5 (0.031)
8 (0.027)		 47 (0.294)
83 (0.282)		 108 (0.675)
203 (0.690)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Hispanic
rs11187025 USA AD
CTR		 0.16
0.18		 0.84
0.82		 4 (0.025)
10 (0.034)		 43 (0.269)
87 (0.295)		 113 (0.706)
198 (0.671)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs3737225 USA AD
CTR		 0.02
0.03		 0.98
0.97		 0 (0.000)
0 (0.000)		 6 (0.038)
17 (0.058)		 153 (0.962)
277 (0.942)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Hispanic
rs7078413 USA AD
CTR		 0.29
0.28		 0.71
0.72		 13 (0.081)
23 (0.078)		 66 (0.413)
119 (0.405)		 81 (0.506)
152 (0.517)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Hispanic
rs7908111 USA AD
CTR		 0.18
0.17		 0.82
0.83		 5 (0.031)
8 (0.027)		 47 (0.294)
83 (0.282)		 108 (0.675)
203 (0.690)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Hispanic
rs11187062 USA AD
CTR		 0.06
0.08		 0.94
0.92		 1 (0.006)
2 (0.007)		 18 (0.113)
43 (0.146)		 141 (0.881)
249 (0.847)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Hispanic
rs12264682 USA AD
CTR		 0.05
0.04		 0.95
0.96		 0 (0.000)
0 (0.000)		 15 (0.094)
23 (0.078)		 144 (0.906)
271 (0.922)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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