AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Reiman, 2007
 Gene: ABCA1  (TGD; ABC1; CERP; ABC-1; HDLDT1)  Entrez Gene
 Protein: ATP-binding cassette, sub-family A member 1  (ATP binding cassette transporter 1; cholesterol efflux regulatory protein; high density lipoprotein deficiency, Tangier type, 1; ATP-binding cassette 1)  ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 13

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2230808 (R1587K) USA, Netherlands AD
CTR		 0.25
0.23		 0.75
0.77		 46 (0.055)
25 (0.046)		 338 (0.400)
197 (0.361)		 460 (0.545)
324 (0.593)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2066714 (I883M) USA, Netherlands AD
CTR		 0.13
0.13		 0.87
0.87		 22 (0.026)
16 (0.029)		 174 (0.203)
115 (0.210)		 662 (0.772)
416 (0.761)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs10820743 USA, Netherlands AD
CTR		 0.28
0.27		 0.72
0.73		 77 (0.090)
43 (0.078)		 333 (0.388)
207 (0.375)		 449 (0.523)
302 (0.547)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2065412 USA, Netherlands AD
CTR		 0.40
0.43		 0.60
0.57		 123 (0.143)
103 (0.187)		 440 (0.512)
271 (0.491)		 296 (0.345)
178 (0.322)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2230805 USA, Netherlands AD
CTR		 0.27
0.28		 0.73
0.72		 57 (0.068)
50 (0.092)		 335 (0.401)
207 (0.382)		 444 (0.531)
285 (0.526)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2297406 USA, Netherlands AD
CTR		 0.31
0.32		 0.69
0.68		 102 (0.119)
51 (0.093)		 329 (0.383)
244 (0.444)		 427 (0.498)
254 (0.463)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2297409 USA, Netherlands AD
CTR		 0.21
0.18		 0.79
0.82		 32 (0.037)
16 (0.029)		 294 (0.344)
164 (0.300)		 528 (0.618)
367 (0.671)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2472496 USA, Netherlands AD
CTR		 0.43
0.42		 0.57
0.58		 147 (0.174)
95 (0.174)		 442 (0.522)
273 (0.500)		 257 (0.304)
178 (0.326)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2482433 USA, Netherlands AD
CTR		 0.28
0.25		 0.72
0.75		 57 (0.068)
32 (0.060)		 354 (0.424)
202 (0.377)		 424 (0.508)
302 (0.563)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2740485 USA, Netherlands AD
CTR		 0.11
0.11		 0.89
0.89		 10 (0.012)
5 (0.009)		 163 (0.194)
110 (0.208)		 666 (0.794)
413 (0.782)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs3890182 USA, Netherlands AD
CTR		 0.13
0.09		 0.87
0.91		 21 (0.024)
5 (0.009)		 185 (0.215)
90 (0.163)		 653 (0.760)
457 (0.828)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4149268 USA, Netherlands AD
CTR		 0.40
0.37		 0.60
0.63		 141 (0.167)
73 (0.136)		 400 (0.475)
254 (0.472)		 301 (0.357)
211 (0.392)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs4149271 USA, Netherlands AD
CTR		 0.23
0.24		 0.77
0.76		 44 (0.053)
33 (0.062)		 288 (0.348)
186 (0.348)		 495 (0.599)
316 (0.591)
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.